L
Leah M. Mayo
Researcher at Linköping University
Publications - 34
Citations - 1859
Leah M. Mayo is an academic researcher from Linköping University. The author has contributed to research in topics: Endocannabinoid system & Facial electromyography. The author has an hindex of 14, co-authored 29 publications receiving 1444 citations. Previous affiliations of Leah M. Mayo include University of Chicago & Molecular and Behavioral Neuroscience Institute.
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Journal ArticleDOI
A selective role for dopamine in stimulus–reward learning
Shelly B. Flagel,Jeremy Clark,Terry E. Robinson,Leah M. Mayo,Alayna Czuj,Ingo Willuhn,Christina A. Akers,Sarah M. Clinton,Paul E. M. Phillips,Huda Akil +9 more
TL;DR: Insight is provided into the neurobiology of a form of stimulus–reward learning that confers increased susceptibility to disorders of impulse control and in individuals with a propensity for this form of learning, reward cues come to powerfully motivate and control behaviour.
Journal ArticleDOI
Amping Up Effort: Effects of d-Amphetamine on Human Effort-Based Decision-Making
Margaret C. Wardle,Michael T. Treadway,Leah M. Mayo,David H. Zald,David H. Zald,Harriet de Wit +5 more
TL;DR: This is the first demonstration in humans that dopaminergic manipulations alter willingness to exert effort for rewards, and the findings help elucidate neurochemical substrates of choice, with implications for neuropsychiatric diseases characterized by dopamine dysfunction and motivational deficits.
Journal ArticleDOI
Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial
Leah M. Mayo,Anna Asratian,Johan Lindé,Maria Morena,Maria Morena,Roosa Haataja,Valter Hammar,Gaëlle Augier,Matthew N. Hill,Matthew N. Hill,Markus Heilig +10 more
TL;DR: The beneficial effects of FAAH inhibition on fear extinction, as well as stress- and affect-related behaviors, provide a strong rationale for developing this drug class as a treatment for posttraumatic stress disorder.
Journal ArticleDOI
Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice.
Leah M. Mayo,Anna Asratian,Johan Lindé,Lovisa Holm,Daniel Nätt,Gaëlle Augier,Niclas Stensson,Haley A. Vecchiarelli,Georgia Balsevich,Robert J. Aukema,Bijar Ghafouri,Primavera A. Spagnolo,Francis S. Lee,Matthew N. Hill,Markus Heilig +14 more
TL;DR: It is suggested that AEA signaling can temper aspects of the stress response and that FAAH inhibition may aid the treatment for stress-related psychiatric disorders, such as PTSD.
Journal ArticleDOI
FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence
Primavera A. Spagnolo,Vijay A. Ramchandani,Melanie L. Schwandt,Laura E. Kwako,David T. George,Leah M. Mayo,Cecilia J. Hillard,Markus Heilig +7 more
TL;DR: This is to the authors' knowledge the first study showing that FAAH C385A variation modulates stress responses in subjects with disorders characterized by increased stress reactivity, and points to the eCB pathway as a promising target for future antistress therapeutics.