Lee Harland

TL;DR: The prerequisites for data commoning are described and an established and growing ecosystem of solutions using the shared 'Investigation-Study-Assay' framework to support that vision are presented.

TL;DR: The challenges and how the Open PHACTS project is hoping to address these challenges technically and socially are laid out.

TL;DR: Functional analysis in stably transfected tissue culture cells suggests that methylation-free CpG islands associated with dual, divergently transcribed promoters possess an independent dominant chromatin opening function and may therefore be major determinants in establishing and maintaining a region of open chromatin at housekeeping gene loci.

TL;DR: This work describes a collaborative effort to produce a prototype Translational Medicine Knowledge Base capable of answering questions relating to clinical practice and pharmaceutical drug discovery and demonstrates the use of Semantic Web technologies in the integration of patient and biomedical data.

TL;DR: Flexible, high-throughput techniques that are driven towards the identification of testable laboratory hypotheses are described that may be initiated independently of 'wet-lab' experimentation, and which may be applied to multiple disease areas.