scispace - formally typeset
Search or ask a question

Showing papers by "Lee Murphy published in 2016"

Journal Article•DOI•
Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

[...]

Nicholas T. Ventham1, Nicholas A. Kennedy1, Alex Adams1, Rahul Kalla1, Simon Heath, KR O’Leary1, Hazel E. Drummond1, Gordan Lauc, Harry Campbell1, Dermot P.B. McGovern2, Vito Annese, Vlatka Zoldoš3, Iain K. Permberton, Manfred Wuhrer4, Manfred Wuhrer5, Daniel Kolarich6, Daryl L. Fernandes, Evropi Theorodorou1, Victoria Merrick1, Daniel I. R. Spencer, Richard A. Gardner, Ray Doran, Archana Shubhakar, Ray Boyapati1, Igor Rudan1, Paolo Lionetti, Irena Trbojević Akmačić, Jasminka Krištić, Frano Vučković, Jerko Štambuk, Mislav Novokmet, Maja Pučić-Baković3, Olga Gornik3, Angelo Andriulli7, Laura Cantoro, G.C. Sturniolo8, Gionata Fiorino, Natalia Manetti, Anna Latiano7, Anna Kohn, Renata D'Incà8, Silvio Danese, Ian D. Arnott1, Colin L. Noble1, Charlie W. Lees1, Alan G. Shand1, Gwo-Tzer Ho, Malcolm G. Dunlop1, Lee Murphy1, Jude Gibson1, Louise Evenden1, Nicola Wrobel, Tamara Gilchrist, Angie Fawkes, Guinevere S. M. Kammeijer, Florent Clerc, Noortje de Haan, Aleksandar Vojta, Ivana Samaržija, Dora Markulin, Marija Klasić, Paula Dobrinić, Yurii S. Aulchenko, Tim van den Heuve, Daisy Jonkers, Marieke Pierik, Simen Vatn, Petr Ricanek, Jørgen Jahnsen, Panpan You, Janne Sølvernes, Anna B. Frengen, Tone Møller Tannæs, Aina Elisabeth Fossum Moen, Fredrik A. Dahl, Jonas Christoffer Lindstrøm, Gunn S. Ekeland, Trond Espen Detlie, Åsa V. Keita, Johan D. Söderholm, Henrik Hjortswang, Jonas Halfvarson, Daniel Bergemalm, Fernando Gomollón, Mauro D'Amato, Leif Törkvist, Fredrik Hjelm, Mats Gullberg, Niklas Nordberg, Anette Ocklind, Erik Pettersson, Daniel Ekman, Mikael Sundell, Eddie Modig, Anne Clémence Veillard, Renaud Schoemans, Dominique Poncelet, Céline Sabatel, Marta Gut, Monica Bayes, C. Casén, Torbjørn Lindahl, Ewa Ciemniejewska, Morten H. Vatn, David C. Wilson1, Ivo Gut9, Elaine R. Nimmo1, Jack Satsangi1 •
University of Edinburgh1, Cedars-Sinai Medical Center2, University of Zagreb3, Leiden University4, VU University Amsterdam5, Max Planck Society6, Casa Sollievo della Sofferenza7, University of Padua8, Pompeu Fabra University9
25 Nov 2016-Nature Communications
TL;DR: Site-specific DNA methylation changes in IBD relate to underlying genotype and associate with cell-specific alteration in gene expression, andSeparated cell data shows that IBD-associated hypermethylation within the TXK promoter region negatively correlates with gene expression in whole-blood and CD8+ T cells, but not other cell types.
Abstract: Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences in 240 newly- ...

171 citations