L
Louise Evenden
Researcher at University of Edinburgh
Publications - 5
Citations - 441
Louise Evenden is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Gene & DNA methylation. The author has an hindex of 4, co-authored 4 publications receiving 342 citations. Previous affiliations of Louise Evenden include Western General Hospital.
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Journal ArticleDOI
Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease
Nicholas T. Ventham,Nicholas A. Kennedy,Alex Adams,Rahul Kalla,Simon Heath,KR O’Leary,Hazel E. Drummond,Gordan Lauc,Harry Campbell,Dermot P.B. McGovern,Vito Annese,Vlatka Zoldoš,Iain K. Permberton,Manfred Wuhrer,Manfred Wuhrer,Daniel Kolarich,Daryl L. Fernandes,Evropi Theorodorou,Victoria Merrick,Daniel I. R. Spencer,Richard A. Gardner,Ray Doran,Archana Shubhakar,Ray Boyapati,Igor Rudan,Paolo Lionetti,Irena Trbojević Akmačić,Jasminka Krištić,Frano Vučković,Jerko Štambuk,Mislav Novokmet,Maja Pučić-Baković,Olga Gornik,Angelo Andriulli,Laura Cantoro,G.C. Sturniolo,Gionata Fiorino,Natalia Manetti,Anna Latiano,Anna Kohn,Renata D'Incà,Silvio Danese,Ian D. Arnott,Colin L. Noble,Charlie W. Lees,Alan G. Shand,Gwo-Tzer Ho,Malcolm G. Dunlop,Lee Murphy,Jude Gibson,Louise Evenden,Nicola Wrobel,Tamara Gilchrist,Angie Fawkes,Guinevere S. M. Kammeijer,Florent Clerc,Noortje de Haan,Aleksandar Vojta,Ivana Samaržija,Dora Markulin,Marija Klasić,Paula Dobrinić,Yurii S. Aulchenko,Tim van den Heuve,Daisy Jonkers,Marieke Pierik,Simen Vatn,Petr Ricanek,Jørgen Jahnsen,Panpan You,Janne Sølvernes,Anna B. Frengen,Tone Møller Tannæs,Aina Elisabeth Fossum Moen,Fredrik A. Dahl,Jonas Christoffer Lindstrøm,Gunn S. Ekeland,Trond Espen Detlie,Åsa V. Keita,Johan D. Söderholm,Henrik Hjortswang,Jonas Halfvarson,Daniel Bergemalm,Fernando Gomollón,Mauro D'Amato,Leif Törkvist,Fredrik Hjelm,Mats Gullberg,Niklas Nordberg,Anette Ocklind,Erik Pettersson,Daniel Ekman,Mikael Sundell,Eddie Modig,Anne Clémence Veillard,Renaud Schoemans,Dominique Poncelet,Céline Sabatel,Marta Gut,Monica Bayes,C. Casén,Torbjørn Lindahl,Ewa Ciemniejewska,Morten H. Vatn,David C. Wilson,Ivo Gut,Elaine R. Nimmo,Jack Satsangi +107 more
TL;DR: Site-specific DNA methylation changes in IBD relate to underlying genotype and associate with cell-specific alteration in gene expression, andSeparated cell data shows that IBD-associated hypermethylation within the TXK promoter region negatively correlates with gene expression in whole-blood and CD8+ T cells, but not other cell types.
Journal ArticleDOI
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants
Reka Nagy,Thibaud Boutin,Jonathan Marten,Jennifer E. Huffman,Shona M. Kerr,Archie Campbell,Louise Evenden,Jude Gibson,Carmen Amador,David M. Howard,Pau Navarro,Andrew D. Morris,Ian J. Deary,Lynne J. Hocking,Sandosh Padmanabhan,Blair H. Smith,Peter K. Joshi,James F. Wilson,Nicholas D. Hastie,Alan F. Wright,Andrew M. McIntosh,Andrew M. McIntosh,David J. Porteous,David J. Porteous,Chris Haley,Veronique Vitart,Caroline Hayward +26 more
TL;DR: It is shown that the combination of deeper genotype imputation and extended phenotype availability make GS:SFHS an attractive resource to carry out association studies to gain insight into the genetic architecture of complex traits.
Journal ArticleDOI
Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases
Mirna Šimurina,Noortje de Haan,Frano Vučković,Nicholas A. Kennedy,Jerko Štambuk,David Falck,Irena Trbojević-Akmačić,Florent Clerc,Genadij Razdorov,Anna Khon,Anna Latiano,Renata D'Incà,Silvio Danese,Stephan R. Targan,Carol J. Landers,Marla Dubinsky,Harry Campbell,Vlatka Zoldoš,Iain K. Permberton,Daniel Kolarich,Daryl L. Fernandes,Evropi Theorodorou,Victoria Merrick,Daniel I. R. Spencer,Richard A. Gardner,Ray Doran,Archana Shubhakar,Ray Boyapati,Igor Rudan,Paolo Lionetti,Jasminka Krištić,Mislav Novokmet,Maja Pučić-Baković,Olga Gornik,Angelo Andriulli,Laura Cantoro,G.C. Sturniolo,Gionata Fiorino,Natalia Manetti,Ian D. Arnott,Colin L. Noble,Charlie W. Lees,Alan G. Shand,Gwo-Tzer Ho,Malcolm G. Dunlop,Lee Murphy,Jude Gibson,Louise Evenden,Nicola Wrobel,Tamara Gilchrist,Angie Fawkes,Guinevere S. M. Kammeijer,Aleksandar Vojta,Ivana Samaržija,Dora Markulin,Marija Klasić,Paula Dobrinić,Yurii S. Aulchenko,Tim van den Heuve,Daisy Jonkers,Marieke Pierik,Dermot P.B. McGovern,Vito Annese,Manfred Wuhrer,Gordan Lauc +64 more
TL;DR: associated levels of IgG Fc-glycosylation with disease (compared to controls) and its clinical features could increase the understanding of mechanisms of CD and UC pathogenesis and be used to develop diagnostics or guide treatment.
Journal ArticleDOI
Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936.
Sarah E. Harris,Sarah E. Harris,Valentina Riggio,Louise Evenden,Tamara Gilchrist,Sarah McCafferty,Lee Murphy,Nicola Wrobel,Adele M. Taylor,Janie Corley,Alison Pattie,Simon R. Cox,Carmen Martin-Ruiz,James G. D. Prendergast,John M. Starr,Riccardo E. Marioni,Riccardo E. Marioni,Riccardo E. Marioni,Ian J. Deary +18 more
TL;DR: Gene Ontology enrichment analysis indicated an enrichment of biological processes involved in the immune system in smokers compared to non-smokers and the expression of transcripts for genes previously associated with stress response, autoimmune disease and cancer were associated with telomere length.
Journal ArticleDOI
Genome-wide methylation profiling in 229 patients with Crohn's disease requiring intestinal resection: Epigenetic analysis of the Trial of prevention of post-operative Crohn's disease (TOPPIC).
Nicholas T. Ventham,Nicholas A. Kennedy,Rahul Kalla,Alex Adams,Alexandra J. Noble,Holly Ennis,Craig Mowat,Malcolm G. Dunlop,Jack Satsangi,Ian D. Arnott,A Cahill,Malcolm D. Smith,Tariq Ahmad,Sreedhar Subramanian,Simon Travis,John C. Morris,P John Hamlin,Anjan Dhar,Chuka U. Nwokolo,Cathryn Edwards,Tom Creed,Stuart Hunegs Bloom,Mohamed Yousif,Linzi Thomas,Simon Campbell,Stephen J. Lewis,Shaji Sebastian,Sandip Sen,Simon Lal,Christopher J. Hawkey,Charles Murray,Fraser Cummings,J Goh,James O. Lindsay,Naila Arebi,L Potts,Aileen McKinley,John M. Thomson,John Todd,M. H. Collie,Ashley Mowat,Daniel R. Gaya,Jack W. Winter,Graham Naismith,Catriona Keerie,Robin J Prescott,Gordan Lauc,Harry Campbell,Dermot P.B. McGovern,Vito Annese,Vlatka Zoldoš,Iain K. Permberton,Manfred Wuhrer,Daniel Kolarich,Daryl L. Fernandes,Evropi Theorodorou,Richard G. Gardner,Ray Doran,Archana Shubhakar,Ray Boyapati,Igor Rudan,Paolo Lionetti,Irena Trbojević Akmačić,Jasminka Krištić,Jerko Štambuk,Mislav Novokmet,Maja Pučić-Baković,Olga Gornik,Angelo Andriulli,Laura Cantoro,G.C. Sturniolo,Gionata Fiorino,Natalia Manetti,Anna Latiano,Anna Kohn,Silvio Danese,Colin L. Noble,Charles Lee,Alan G. Shand,Gwo-Tzer Ho,Lee Murphy,Jude Gibson,Louise Evenden,Nicola Wrobel,Tamara Gilchrist,Angie Fawkes,Guinevere S. M. Kammeijer,Florent Clerc,Noortje de Haan,Aleksandar Vojta,Ivana Samaržija,Dora Markulin,Marija Klasić,Paula Dobrinić,Yurii S. Aulchenko,Tim van den Heuve,Daisy Jonkers,Marieke Pierik +97 more
TL;DR: The TOPPIC trial as discussed by the authors was a placebo-controlled, randomized controlled trial of 6-mercaptopurine at 29 UK centers in patients with Crohn's disease recurrence following intestinal resection between 2008 and 2012.