W
Weihong Tu
Researcher at University of Central Florida
Publications - 5
Citations - 1142
Weihong Tu is an academic researcher from University of Central Florida. The author has contributed to research in topics: AMPA receptor & Glutamate receptor. The author has an hindex of 5, co-authored 5 publications receiving 1042 citations. Previous affiliations of Weihong Tu include Louisiana State University.
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Journal ArticleDOI
DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke
Weihong Tu,Xin Xu,Lisheng Peng,Xiaofen Zhong,Wenfeng Zhang,Mangala M. Soundarapandian,Cherine Balel,Manqi Wang,Nali Jia,Wen Zhang,Frank Lew,Sic L. Chan,Yanfang Chen,Youming Lu +13 more
TL;DR: C cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B protein complex in the cortex of adult mice and this interaction acts as a central mediator for stroke damage.
Journal ArticleDOI
Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity
Dohoon Kim,Christopher Lee Frank,Christopher Lee Frank,Matthew M. Dobbin,Rachel K. Tsunemoto,Weihong Tu,Peter L. Peng,Ji-Song Guan,Byung-Hoon Lee,Lily Y. Moy,Paola Giusti,Nisha Broodie,Ralph Mazitschek,Ivanna Delalle,Stephen J. Haggarty,Rachael L. Neve,Youming Lu,Li-Huei Tsai,Li-Huei Tsai +18 more
TL;DR: This work shows that deregulation of histone deacetylase 1 (HDAC1) activity by p25/Cdk5 induces aberrant cell-cycle activity and double-strand DNA breaks leading to neurotoxicity, and outlines a pathological signaling pathway illustrating the importance of maintaining HDAC1 activity in the adult neuron.
Journal ArticleDOI
ADAR2-Dependent RNA Editing of AMPA Receptor Subunit GluR2 Determines Vulnerability of Neurons in Forebrain Ischemia
Peter L. Peng,Xiafen Zhong,Weihong Tu,Mangala M. Soundarapandian,Peter Molner,Dong-Ya Zhu,Lorraine Lau,Shu Hong Liu,Fang Liu,Youming Lu +9 more
TL;DR: It is shown that forebrain ischemia in adult rats selectively reduces expression of ADAR2 enzyme and, hence, disrupts RNA Q/R site editing of GluR2 subunit in vulnerable neurons, which determines vulnerability of neurons in the rat hippocampus to fore brain ischemic insult.
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EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation
Ying Yang,Xiaogang Shu,Xiaogang Shu,Dan Liu,You Shang,You Shang,Yan Wu,Yan Wu,Lei Pei,Xin Xu,Qing Tian,Jian Zhang,Kun Qian,Ya-Xian Wang,Ronald S. Petralia,Weihong Tu,Ling-Qiang Zhu,Jian-Zhi Wang,Youming Lu,Youming Lu +19 more
TL;DR: It is shown that EPAC null mutation impairs long-term potentiation (LTP) and that this impairment is paralleled with the severe deficits in spatial learning and social interactions and is mediated in a direct manner by miR-124 transcription and Zif268 translation.
Journal ArticleDOI
Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures.
Mangala M. Soundarapandian,Di Wu,Xiaofen Zhong,Ronald S. Petralia,Lisheng Peng,Weihong Tu,Youming Lu +6 more
TL;DR: Whole‐cell patch clamp recordings demonstrate that genetic deletion of the Kir6.1/SUR1 channels enhances glutamate release at CA3 synapses and inhibits seizure responses and possibly acts via limiting excitatory glutamate release.