Lei Xiong

TL;DR: This work proposes a new method for determining the target genes of transcriptional enhancers in specific cells and tissues, and discovers three major co-regulation modes of enhancers and finds defense-related genes often simultaneously regulated by multiple enhancers bound by different transcription factors.

TL;DR: A causal link between aberrant enhancer hypomethylation and C/EBPβ over-expression is supported, thereby contributing to hepatocarcinogenesis through global transcriptional reprogramming.

TL;DR: Y1 overexpression contributes to EZH2 recruitment for H3K27me3‐mediated silencing of tumour‐suppressive microRNAs, thereby activating NF‐κB signalling in hepatocarcinogenesis.

TL;DR: It is found that a therapeutic oligonucleotide-based strategy, which utilized PAM to differentiate cancer mutation from normal, afforded high specificity to the extent of a single nucleotide substitution, and may serve as a useful approach to target cancer-defining mutations with specificity.