M
Myth T.S. Mok
Researcher at The Chinese University of Hong Kong
Publications - 43
Citations - 1268
Myth T.S. Mok is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Gene & Gene silencing. The author has an hindex of 17, co-authored 39 publications receiving 1011 citations. Previous affiliations of Myth T.S. Mok include University of Sydney & Millennium Institute.
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Journal ArticleDOI
microRNA-7 Is a Novel Inhibitor of YY1 Contributing to Colorectal Tumorigenesis
Ning Zhang,Xiang Li,Chung Wah Wu,Yujuan Dong,Mu-Yan Cai,Myth T.S. Mok,Huating Wang,Jingkao Chen,Simon S.M. Ng,Minhu Chen,Joseph J.Y. Sung,Jun Yu +11 more
TL;DR: MiR-7 is a novel miRNA with tumor suppressive function in colon cancer by targeting oncogenic YY1, which promotes colon cancer growth through inhibiting p53 and promoting Wnt signaling pathways and serves as an independent prognostic biomarker for CRC patients.
Journal ArticleDOI
Reconstruction of enhancer–target networks in 935 samples of human primary cells, tissues and cell lines
Qin Cao,Christine Anyansi,Christine Anyansi,Xihao Hu,Liangliang Xu,Lei Xiong,Wenshu Tang,Myth T.S. Mok,Chao Cheng,Xiaodan Fan,Mark Gerstein,Alfred S. L. Cheng,Kevin Y. Yip +12 more
TL;DR: This work proposes a new method for determining the target genes of transcriptional enhancers in specific cells and tissues, and discovers three major co-regulation modes of enhancers and finds defense-related genes often simultaneously regulated by multiple enhancers bound by different transcription factors.
Journal ArticleDOI
Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma
Man Liu,Jingying Zhou,Xiaoyu Liu,Yu Feng,Weiqin Yang,Feng Wu,Otto Ka-Wing Cheung,Hanyong Sun,Hanyong Sun,Xuezhen Zeng,Wenshu Tang,Myth T.S. Mok,John Wong,Philip Chun Yeung,Paul B.S. Lai,Zhiwei Chen,Hongchuan Jin,Jie Chen,Stephen L. Chan,Anthony W.H. Chan,Ka Fai To,Joseph J.Y. Sung,Minhu Chen,Alfred S. L. Cheng +23 more
TL;DR: It is shown how non-tumour-intrinsic properties in the desmoplastic microenvironment can be exploited to reinstate immunosurveillance, providing readily translatable combination strategies to empower HCC immunotherapy.
Journal ArticleDOI
Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?
Paul K. Lovelock,Paul K. Lovelock,Amanda B. Spurdle,Myth T.S. Mok,Daniel J. Farrugia,Sunil R. Lakhani,Sunil R. Lakhani,Sue Healey,Stephen Arnold,Daniel D. Buchanan,kConFab Investigators,Fergus J. Couch,Berik R. Henderson,David E. Goldgar,Sean V. Tavtigian,Georgia Chenevix-Trench,Melissa A. Brown +16 more
TL;DR: Results show that multifactorial likelihood analysis, which incorporates sequence conservation, co-inheritance, segregation, and tumour immunohistochemical analysis, may improve classification of variants, and raise the possibility that A1708V and R1699Q may be associated with a low or moderate risk of cancer.
Journal ArticleDOI
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
Lei Xiong,Feng Wu,Qiong Wu,Liangliang Xu,Otto Ka-Wing Cheung,Wei Kang,Myth T.S. Mok,Lemuel L. M. Szeto,Cheuk-Yin Lun,Raymond W.M. Lung,Jinglin Zhang,Ken H. Yu,Sau Dan Lee,Guangcun Huang,Chiou-Miin Wang,Joseph Liu,Zhuo Yu,Dae-Yeul Yu,Jian-Liang Chou,Wan-Hong Huang,Bo Feng,Yue-Sun Cheung,Paul B.S. Lai,Patrick Tan,Patrick Tan,Nathalie Wong,Michael W.Y. Chan,Tim H M Huang,Kevin Y. Yip,Alfred S. L. Cheng,Ka Fai To +30 more
TL;DR: A causal link between aberrant enhancer hypomethylation and C/EBPβ over-expression is supported, thereby contributing to hepatocarcinogenesis through global transcriptional reprogramming.