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Yanxin Liu
Researcher at University of California, San Francisco
Publications - 43
Citations - 2506
Yanxin Liu is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Folding (chemistry) & Downhill folding. The author has an hindex of 19, co-authored 42 publications receiving 1746 citations. Previous affiliations of Yanxin Liu include University of California, Berkeley & Florida International University.
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Journal ArticleDOI
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
David E. Gordon,Joseph Hiatt,Mehdi Bouhaddou,Veronica V. Rezelj,Svenja Ulferts,Hannes Braberg,Alexander S. Jureka,Kirsten Obernier,Jeffrey Z. Guo,Jyoti Batra,Robyn M. Kaake,Andrew R. Weckstein,Tristan W. Owens,Meghna Gupta,Sergei Pourmal,Erron W. Titus,Merve Cakir,Margaret Soucheray,Michael J. McGregor,Zeynep Cakir,Gwendolyn M. Jang,Matthew J. O’Meara,Tia A. Tummino,Ziyang Zhang,Helene Foussard,Ajda Rojc,Yuan Zhou,Dmitry Kuchenov,Ruth Hüttenhain,Jiewei Xu,Manon Eckhardt,Danielle L. Swaney,Jacqueline M. Fabius,Manisha Ummadi,Beril Tutuncuoglu,Ujjwal Rathore,Maya Modak,Paige Haas,Kelsey M. Haas,Zun Zar Chi Naing,Ernst H. Pulido,Ying Shi,Inigo Barrio-Hernandez,Danish Memon,Eirini Petsalaki,Alistair Dunham,Miguel Correa Marrero,David F. Burke,Cassandra Koh,Thomas Vallet,Jesus A. Silvas,Caleigh M. Azumaya,Christian B. Billesbølle,Axel F. Brilot,Melody G. Campbell,Melody G. Campbell,Amy Diallo,Miles Sasha Dickinson,Devan Diwanji,Nadia Herrera,Nick Hoppe,Huong T. Kratochvil,Yanxin Liu,Gregory E. Merz,Michelle Moritz,Henry C. Nguyen,Carlos Nowotny,Cristina Puchades,Alexandrea N. Rizo,Ursula Schulze-Gahmen,Amber M. Smith,Ming Sun,Iris D. Young,Jianhua Zhao,Daniel Asarnow,Justin T Biel,Alisa Bowen,Julian R. Braxton,Jen Chen,Cynthia M. Chio,Un Seng Chio,Ishan Deshpande,Loan Doan,Bryan Faust,Sebastian Flores,Mingliang Jin,Kate Kim,Victor L Lam,Fei Li,Junrui Li,Y. Li,Yang Li,Xi Liu,Megan Lo,Kyle E. Lopez,Arthur Alves de Melo,Frank R. Moss,Phuong Nguyen,Joana Paulino,Komal Ishwar Pawar,Jessica K. Peters,Thomas H. Pospiech,Maliheh Safari,Smriti Sangwan,Kaitlin Schaefer,Paul V. Thomas,Aye C. Thwin,Raphael Trenker,Eric Tse,Tsz Kin Martin Tsui,Feng Wang,Natalie Whitis,Zanlin Yu,Kaihua Zhang,Yang Zhang,Fengbo Zhou,Daniel J. Saltzberg,Anthony J. Hodder,Amber S. M. Shun-Shion,Daniel M. Williams,Kris M. White,Romel Rosales,Thomas Kehrer,Lisa Miorin,Elena Moreno,Arvind H. Patel,Suzannah J. Rihn,Mir M. Khalid,Albert Vallejo-Gracia,Parinaz Fozouni,Parinaz Fozouni,Camille R. Simoneau,Camille R. Simoneau,Theodore L. Roth,David Wu,Mohd Anisul Karim,Maya Ghoussaini,Ian Dunham,Francesco Berardi,Sebastian Weigang,Maxime Chazal,Jisoo Park,James Logue,Marisa McGrath,Stuart Weston,Robert Haupt,C. James Hastie,Matthew Elliott,Fiona Brown,Kerry A. Burness,Elaine Reid,Mark Dorward,Clare Johnson,Stuart G. Wilkinson,Anna Geyer,Daniel M. Giesel,Carla Baillie,Samantha Raggett,Hannah Leech,Rachel Toth,Nicola Goodman,Kathleen C. Keough,Abigail L. Lind,Reyna J. Klesh,Kafi R. Hemphill,Jared Carlson-Stevermer,Jennifer Oki,Kevin Holden,Travis J. Maures,Katherine S. Pollard,Katherine S. Pollard,Andrej Sali,David A. Agard,Yifan Cheng,James S. Fraser,Adam Frost,Natalia Jura,Tanja Kortemme,Aashish Manglik,Daniel R. Southworth,Robert M. Stroud,Dario R. Alessi,Paul Davies,Matthew B. Frieman,Trey Ideker,Carmen Abate,Nolwenn Jouvenet,Nolwenn Jouvenet,Georg Kochs,Brian K. Shoichet,Melanie Ott,Melanie Ott,Massimo Palmarini,Kevan M. Shokat,Adolfo García-Sastre,Jeremy A. Rassen,Robert Grosse,Oren S. Rosenberg,Kliment A. Verba,Christopher F. Basler,Marco Vignuzzi,Andrew A. Peden,Pedro Beltrao,Nevan J. Krogan +203 more
TL;DR: The authors identified shared biology and host-directed drug targets to prioritize therapeutics with potential for rapid deployment against current and future coronavirus outbreaks, and found that individuals with genotypes corresponding to higher soluble IL17RA levels in plasma are at decreased risk of COVID-19 hospitalization.
Journal ArticleDOI
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase
Kliment A. Verba,Ray Yu-Ruei Wang,Akihiko Arakawa,Yanxin Liu,Mikako Shirouzu,Shigeyuki Yokoyama,David A. Agard +6 more
TL;DR: A 3.9 angstrom cryo–electron microscopy structure of the Hsp90-Cdc37-Cdk4 kinase complex is determined and a unifying conceptual and mechanistic models of chaperone-kinase interactions are proposed.
Journal ArticleDOI
Challenges in protein-folding simulations
TL;DR: Recent progress in the simulation of three common model systems for protein folding is reviewed, and how recent advances in technology and theory are allowing protein folding simulations to address their current shortcomings is discussed.
Journal ArticleDOI
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
Michael Schoof,Bryan Faust,R.A. Saunders,Smriti Sangwan,Veronica V. Rezelj,Nick Hoppe,Morgane Boone,Christian B. Billesbølle,Cristina Puchades,Caleigh M. Azumaya,Huong T. Kratochvil,M. Zimanyi,Ishan Deshpande,Jiahao Liang,S. Dickinson,Henry C. Nguyen,Cynthia M. Chio,Gregory E. Merz,Michael C. Thompson,Devan Diwanji,Kaitlin Schaefer,Aditya A. Anand,Niv Dobzinski,Beth S. Zha,Camille R. Simoneau,Camille R. Simoneau,Kristoffer E. Leon,Kristoffer E. Leon,Kris M. White,Un Seng Chio,Meghna Gupta,Mingliang Jin,Fei Li,Yanxin Liu,Kaihua Zhang,David Bulkley,Ming Sun,Amber M. Smith,Alexandrea N. Rizo,Frank R. Moss,Axel F. Brilot,Sergei Pourmal,Raphael Trenker,Thomas H. Pospiech,Sayan Gupta,Benjamin Barsi-Rhyne,Vladislav Belyy,A.W. Barile-Hill,Silke Nock,Yuwei Liu,Nevan J. Krogan,Corie Y. Ralston,Danielle L. Swaney,Adolfo García-Sastre,Melanie Ott,Melanie Ott,Marco Vignuzzi,Peter Walter,Aashish Manglik +58 more
TL;DR: Nanobodies that bind tightly to spike and efficiently neutralize SARS-CoV-2 in cells are reported, which enables aerosol-mediated delivery of this potent neutralizer directly to the airway epithelia.
Journal ArticleDOI
Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel
Yong Wang,Yanxin Liu,Hannah A. DeBerg,Takeshi Nomura,Melinda Tonks Hoffman,Paul R. Rohde,Klaus Schulten,Boris Martinac,Boris Martinac,Paul R. Selvin +9 more
TL;DR: Measurements of the distance changes on liposome-reconstituted MscL transmembrane α-helices, using a ‘virtual sorting’ single-molecule fluorescence energy transfer confirm that the channel opens via the helix-tilt model and the open pore reaches 2.8 nm in diameter.