Leslie Stratford-Perricaudet

TL;DR: Observations suggest the feasibility of in vivo CFTR gene transfer as therapy for the pulmonary manifestations of CF.

TL;DR: Adenovirus vectors appear to be a promising means for in vivo transfer of therapeutic genes into the central nervous system.

TL;DR: The experiments reported here document the feasibility of using adenovirus for the direct delivery in vivo of a gene to restore an impaired metabolism and observe the relatively long-term presence of the transferred gene.

TL;DR: Current recombinant adenoviral vectors may have clinical applications in gene therapy for acute hepatic disorders, and the transduced hepatocytes do not appear to persist in vivo because the percentage of hepatocytes expressing beta-gal declined over time.

TL;DR: A human bronchial xenograft model is used for studying the efficiency and biology of in vivo gene transfer into human Bronchial epithelia with recombinant E1 deleted adenoviruses to address important issues that relate to safety and in vivo efficacy of recombinant adenOViruses for gene delivery into the human airway.