L
Lynette Peddle
Researcher at Memorial University of Newfoundland
Publications - 26
Citations - 1828
Lynette Peddle is an academic researcher from Memorial University of Newfoundland. The author has contributed to research in topics: Single-nucleotide polymorphism & Population. The author has an hindex of 20, co-authored 26 publications receiving 1742 citations. Previous affiliations of Lynette Peddle include St. John's University.
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Journal ArticleDOI
Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis
Craig T. Jordan,Li Cao,Elisha D.O. Roberson,Shenghui Duan,Cynthia Helms,Rajan P. Nair,Kristina Callis Duffin,Philip E. Stuart,David E. Goldgar,Genki Hayashi,Emily Olfson,Bing Jian Feng,Clive R. Pullinger,John P. Kane,Carol Wise,Raphaela Goldbach-Mansky,Michelle A. Lowes,Lynette Peddle,Vinod Chandran,Wilson Liao,Proton Rahman,Gerald G. Krueger,Dafna D. Gladman,James T. Elder,Alan Menter,Anne M. Bowcock +25 more
TL;DR: Fifteen additional rare missense variants in CARD14 are described, their distribution in seven psoriasis cohorts, and their effects on NF-kB activation and the transcriptome of keratinocytes, to contribute to the understanding of the genetic basis of Psoriasis and illustrate the challenges faced in identifying pathogenic variants in common disease.
Journal ArticleDOI
Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies
Joseph DeYoung,Maria Karayiorgou,J. Louw Roos,Herman Pretorious,Gabriel Bedoya,Jorge Ospina,Andres Ruiz-Linares,Andres Ruiz-Linares,António Macedo,Joana Almeida Palha,Peter Heutink,Yurii S. Aulchenko,Ben A. Oostra,Cornelia M. van Duijn,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Teppo Varilo,Lynette Peddle,Proton Rahman,Giovanna Piras,Maria Monne,Sarah S. Murray,Luana Galver,Leena Peltonen,Chiara Sabatti,Andrew Collins,Nelson B. Freimer,Nelson B. Freimer +27 more
TL;DR: LD is assayed in large samples from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22 to determine the strategy for selecting markers for association studies.
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Association of interleukin-23 receptor variants with ankylosing spondylitis.
Proton Rahman,Robert D. Inman,Dafna D. Gladman,Jeff Reeve,Lynette Peddle,Walter P. Maksymowych +5 more
TL;DR: This concurrent analysis of 3 distinct AS populations and their regional controls demonstrates a disease association with the IL-23R locus and implicates the same polymorphisms associated with IBD and psoriasis.
Journal ArticleDOI
CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis.
Proton Rahman,Susan J. Bartlett,Fotios Siannis,Fawnda Pellett,Vernon T. Farewell,Lynette Peddle,Catherine T Schentag,C.A. Alderdice,Sean Hamilton,Majed Khraishi,Y. Tobin,Donna Hefferton,Dafna D. Gladman +12 more
TL;DR: CARD15 represents a pleiotropic autoimmune gene and is the first non-MHC gene to be associated with PsA, supported by epidemiological studies that note an increased incidence of psoriasis in subjects with Crohn.
Journal ArticleDOI
Association between the interleukin-1 family gene cluster and psoriatic arthritis.
Proton Rahman,Shuying Sun,Lynette Peddle,Tara Snelgrove,William Melay,Celia M. T. Greenwood,Dafna D. Gladman +6 more
TL;DR: The IL1 locus appears to be a high-priority susceptibility locus in PsA, with at least 2 independent regions that confer increased risk of disease.