Yongqing Chen

TL;DR: It is proposed that, after a triggering event that can include epidermal injury, rare gain-of-function mutations in CARD14 initiate a process that includes inflammatory cell recruitment by keratinocytes, which perpetuates a vicious cycle of epidersmal inflammation and regeneration, a cycle which is the hallmark of psoriasis.

TL;DR: CANDLE syndrome is caused by mutations in PSMB8, a gene recently reported to cause "JMP" syndrome in adults, and IFN may be a key mediator of the inflammatory response and may present a therapeutic target.

TL;DR: Function evaluation revealed that these mutations variably affect transcription, protein expression, protein folding, proteasome assembly, and, ultimately, proteAsome activity, and defects in proteasomesome formation and function were recapitulated by siRNA-mediated knockdown of the respective subunits in primary fibroblasts from healthy individuals.

TL;DR: Rabbit antibodies elicited by nine HTLV-I Env synthetic peptides were used to react with the native HTLV envelope glycoproteins in an antibody-dependent cellular cytotoxicity (ADCC) assay to map the type-specific regions on human T cell leukemia virus (HTLV) envelope gly coproteins.