L
Li Guan
Researcher at University of Michigan
Publications - 7
Citations - 89
Li Guan is an academic researcher from University of Michigan. The author has contributed to research in topics: Expression quantitative trait loci & Trait. The author has an hindex of 3, co-authored 6 publications receiving 49 citations.
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Journal ArticleDOI
A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study
Aino Latva-Rasku,Miikka-Juhani Honka,Alena Stančáková,Heikki A. Koistinen,Heikki A. Koistinen,Johanna Kuusisto,Li Guan,Alisa K. Manning,Alisa K. Manning,Heather M. Stringham,Anna L. Gloyn,Anna L. Gloyn,Anna L. Gloyn,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Francis S. Collins,Karen L. Mohlke,Laura J. Scott,Tomi Karjalainen,Lauri Nummenmaa,Michael Boehnke,Pirjo Nuutila,Pirjo Nuutila,Markku Laakso +24 more
TL;DR: Data demonstrate that the p.P50T substitution of AKT2 influences insulin-mediated GU in multiple insulin-sensitive tissues and may explain, at least in part, the increased risk of type 2 diabetes in p.
Journal ArticleDOI
Interactions between genetic variation and cellular environment in skeletal muscle gene expression
D. Leland Taylor,D. Leland Taylor,David A. Knowles,Laura J. Scott,Andrea H. Ramirez,Francesco Paolo Casale,Brooke N. Wolford,Li Guan,Arushi Varshney,Ricardo D’Oliveira Albanus,Stephen C. J. Parker,Narisu Narisu,Peter S. Chines,Michael R. Erdos,Ryan P. Welch,Leena Kinnunen,Jouko Saramies,Jouko Sundvall,Timo A. Lakka,Markku Laakso,Jaakko Tuomilehto,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Oliver Stegle,Michael Boehnke,Ewan Birney,Francis S. Collins +27 more
TL;DR: Opportunities of using allele-specific expression (ASE) to discover cis-acting genotype-environment interactions (GxE)—genetic effects on gene expression that depend on an environmental condition are explored.
Posted ContentDOI
ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition.
Julia S. El-Sayed Moustafa,Anne U. Jackson,Sarah M Brotman,Li Guan,Sergio Villicaňa,Amy L. Roberts,Antonino Zito,Antonino Zito,Lori L. Bonnycastle,Michael R. Erdos,Narisu Narisu,Heather M. Stringham,Ryan P. Welch,Tingfen Yan,Timo A. Lakka,Stephen C. J. Parker,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Francis S. Collins,Päivi Pajukanta,Michael Boehnke,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Markku Laakso,Mario Falchi,Jordana T. Bell,Laura J. Scott,Karen L. Mohlke,Kerrin S. Small +30 more
TL;DR: It is demonstrated that at-risk individuals have lower background ACE2 levels in this highly relevant tissue, and further studies will be required to establish how this may contribute to increased COVID-19 severity.
Journal ArticleDOI
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19
Julia S. El-Sayed Moustafa,Anne U. Jackson,Sarah M Brotman,Li Guan,S M Villicana,Amy L. Roberts,Antonino Zito,Lori L. Bonnycastle,Michael R. Erdos,Narisu Narisu,Heather M. Stringham,Ryan P. Welch,Ting Yan,Timo A. Lakka,Stephen C. J. Parker,Jaakko Tuomilehto,Jeffrey Seow,Carl Graham,Isabella Huettner,Sam Acors,Neophytos Kouphou,Samuel Wadge,E. Loverne Duncan,Claire J. Steves,Katie J. Doores,Michael H. Malim,Francis S. Collins,Päivi Pajukanta,Michael Boehnke,Heikki A. Koistinen,Markku Laakso,Mario Falchi,Jordana T. Bell,Laura J. Scott,Karen L. Mohlke,Kerrin S. Small +35 more
TL;DR: In this article , the authors investigated phenotypic and genetic factors associated with subcutaneous adipose tissue expression of ACE2, which acts as a receptor for SARS-CoV-2 cellular entry.
Interactions between genetic variation and cellular environment in skeletal muscle gene expression
D. Leland Taylor,D. Leland Taylor,David A. Knowles,Laura J. Scott,Andrea H. Ramirez,Francesco Paolo Casale,Brooke N. Wolford,Li Guan,Arushi Varshney,Ricardo D’Oliveira Albanus,Stephen C. J. Parker,Narisu Narisu,Peter S. Chines,Michael R. Erdos,Ryan P. Welch,Leena Kinnunen,Jouko Saramies,Jouko Sundvall,Timo A. Lakka,Markku Laakso,Jaakko Tuomilehto,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Oliver Stegle,Michael Boehnke,Ewan Birney,Francis S. Collins +27 more
TL;DR: Opportunities of using allele-specific expression (ASE) to discover cis acting genotype-environment interactions (GxE) - genetic effects on gene expression that depend on an environmental condition are explored.