T
Tingfen Yan
Researcher at National Institutes of Health
Publications - 3
Citations - 44
Tingfen Yan is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genome-wide association study & Epigenomics. The author has an hindex of 2, co-authored 3 publications receiving 19 citations.
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Journal ArticleDOI
Single-cell transcriptomics from human pancreatic islets: sample preparation matters.
Lori L. Bonnycastle,Derek Gildea,Tingfen Yan,Narisu Narisu,Amy J. Swift,Tyra G. Wolfsberg,Michael R. Erdos,Francis S. Collins +7 more
TL;DR: A detailed comparison of scRNA-seq data generated with islets isolated from a human donor but processed according to four treatment strategies found significant and reproducible differences in the proportion of cell types identified, and more minor effects on cell-specific patterns of gene expression.
Posted ContentDOI
ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition.
Julia S. El-Sayed Moustafa,Anne U. Jackson,Sarah M Brotman,Li Guan,Sergio Villicaňa,Amy L. Roberts,Antonino Zito,Antonino Zito,Lori L. Bonnycastle,Michael R. Erdos,Narisu Narisu,Heather M. Stringham,Ryan P. Welch,Tingfen Yan,Timo A. Lakka,Stephen C. J. Parker,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Francis S. Collins,Päivi Pajukanta,Michael Boehnke,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Markku Laakso,Mario Falchi,Jordana T. Bell,Laura J. Scott,Karen L. Mohlke,Kerrin S. Small +30 more
TL;DR: It is demonstrated that at-risk individuals have lower background ACE2 levels in this highly relevant tissue, and further studies will be required to establish how this may contribute to increased COVID-19 severity.
Journal ArticleDOI
Genetic effects on liver chromatin accessibility identify disease regulatory variants.
Kevin W Currin,Michael R. Erdos,Narisu Narisu,Vivek Rai,Swarooparani Vadlamudi,Hannah J Perrin,Jacqueline R. Idol,Tingfen Yan,Ricardo D’Oliveira Albanus,K. Alaine Broadaway,Amy S. Etheridge,Lori L. Bonnycastle,Peter Orchard,John P. Didion,Amarjit S. Chaudhry,Beatrice B. Barnabas,Sean Black,Gerard G. Bouffard,Shelise Brooks,Holly Coleman,Lyudmila Dekhtyar,Joel Han,S. L. Ho,Juyun Kim,Richelle Legaspi,Quino Maduro,Catherine A. Masiello,Jennifer C. McDowell,Casandra Montemayor,James C. Mullikin,Morgan Park,Nancy Riebow,Karen Schandler,Brian P. Schmidt,Christina Sison,Sirintorn Stantripop,James W. Thomas,Pamela J. Thomas,Meghana Vemulapalli,Alice C. Young,Federico Innocenti,Erin G. Schuetz,Laura J. Scott,Stephen C. J. Parker,Francis S. Collins,Karen L. Mohlke +45 more
TL;DR: In this article, the authors mapped caQTLs in human liver tissue in 20 liver samples and identified 3,123 caQTs in a limited set of human tissues and predicted target genes for 861 caQT peaks using proximity, chromatin interactions, correlation with promoter accessibility or gene expression, and colocalization with expression QTLs.