A
Amy L. Roberts
Researcher at King's College London
Publications - 23
Citations - 1192
Amy L. Roberts is an academic researcher from King's College London. The author has contributed to research in topics: Lupus erythematosus & Medicine. The author has an hindex of 13, co-authored 19 publications receiving 868 citations. Previous affiliations of Amy L. Roberts include University of London & Imperial College London.
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Journal ArticleDOI
Cell type–specific genetic regulation of gene expression across human tissues
Sarah Kim-Hellmuth,Sarah Kim-Hellmuth,François Aguet,Meritxell Oliva,Manuel Muñoz-Aguirre,Silva Kasela,Valentin Wucher,Stephane E. Castel,Andrew R. Hamel,Andrew R. Hamel,Ana Viñuela,Amy L. Roberts,Serghei Mangul,Serghei Mangul,Xiaoquan Wen,Gao Wang,Alvaro N. Barbeira,Diego Garrido-Martín,Brian B. Nadel,Yuxin Zou,Rodrigo Bonazzola,Jie Quan,Andrew A. Brown,Andrew A. Brown,Angel Martinez-Perez,José Manuel Soria,Gad Getz,Gad Getz,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Kerrin S. Small,Matthew Stephens,Hualin S. Xi,Hae Kyung Im,Roderic Guigó,Ayellet V. Segrè,Ayellet V. Segrè,Barbara E. Stranger,Barbara E. Stranger,Kristin G. Ardlie,Tuuli Lappalainen +40 more
TL;DR: A growing number of in silico cell type deconvolution methods and associated reference panels with cell type–specific marker genes enable the robust estimation of the enrichment of specific cell types from bulk tissue gene expression data.
Journal ArticleDOI
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
David L. Morris,Yujun Sheng,Yujun Sheng,Yan Zhang,Yong-Fei Wang,Zhengwei Zhu,Philip Tombleson,Lingyan Chen,Deborah S. Cunninghame Graham,James Bentham,Amy L. Roberts,Ruoyan Chen,Xianbo Zuo,Ting-You Wang,Leilei Wen,Chao Yang,Lu Liu,Lulu Yang,Feng Li,Yuanbo Huang,Xianyong Yin,Sen Yang,Lars Rönnblom,Barbara G. Fürnrohr,Reinhard E. Voll,Georg Schett,Nathalie Costedoat-Chalumeau,Patrick M. Gaffney,Yu-Lung Lau,Xuejun Zhang,Xuejun Zhang,Wanling Yang,Yong Cui,Yong Cui,Timothy J. Vyse +34 more
TL;DR: This study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations, and suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.
Journal ArticleDOI
The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes
Benjamin Rhodes,Barbara G. Fürnrohr,Amy L. Roberts,George Tzircotis,Georg Schett,Tim D. Spector,Timothy J. Vyse +6 more
TL;DR: The R77H variant impairs a broad range of CR3 effector functions in human monocytes, and how perturbation of this pathway may predispose to SLE is discussed.
Journal ArticleDOI
Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus
Christopher A. Odhams,Christopher A. Odhams,Amy L. Roberts,Susan K. Vester,Carolina S. T. Duarte,Charlie T. Beales,Alexander J. Clarke,Sonja Lindinger,Sonja Lindinger,Samuel J. Daffern,Samuel J. Daffern,Antonino Zito,Lingyan Chen,Lingyan Chen,Leonardo Jones,Lora Boteva,Lora Boteva,David L. Morris,Kerrin S. Small,Michelle M. A. Fernando,Deborah S. Cunninghame Graham,Timothy J. Vyse +21 more
TL;DR: Modulation in gene expression affected by the combination of two hallmarks of SLE is revealed: CXorf21 expression increases in a both an IFN-inducible and sex-specific manner.
Journal ArticleDOI
Genomic Pathology of SLE-Associated Copy-Number Variation at the FCGR2C/FCGR3B/FCGR2B Locus
Michael Mueller,Paula Barros,Abigail S. Witherden,Amy L. Roberts,Zhou Zhang,Helmut Schaschl,Chack-Yung Yu,Matthew E. Hurles,Catherine Schaffner,R. Andres Floto,Laurence Game,Karyn Meltz Steinberg,Richard K. Wilson,Tina Graves,Evan E. Eichler,H. Terence Cook,Timothy J. Vyse,Timothy J. Aitman +17 more
TL;DR: It is concluded that FCGR3B deletion juxtaposes the 5'-regulatory sequences of FC GR2C with the coding sequence of FCGR2B, creating a chimeric gene that results in an ectopic accumulation of FcγRIIb on NK cells and provides an explanation for SLE risk associated with reduced FC GR3B gene copy number.