[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome assemblies of uncultivated organisms. Assembly of single-cell data is challenging because of highly non-uniform read coverage as well as elevated levels of sequencing errors and chimeric reads. We describe SPAdes, a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler (specialized for single-cell data) and on popular assemblers Velvet and SoapDeNovo (for multicell data). SPAdes generates single-cell assemblies, providing information about genomes of uncultivatable bacteria that vastly exceeds what may be obtained via traditional metagenomics studies. SPAdes is available online ( http://bioinf.spbau.ru/spades ). It is distributed as open source software.

SPAdes, a new genome assembly algorithm and its applications to single-cell sequencing ( 7th Annual SFAF Meeting, 2012)

Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

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Principles Of Fluorescence Spectroscopy

Applications in Theranostics Guanying Chen,*,†,‡ Hailong Qiu,†,‡ Paras N. Prasad,*,‡,§ and Xiaoyuan Chen* †School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China ‡Department of Chemistry and the Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, State University of New York, Buffalo, New York 14260, United States Department of Chemistry, Korea University, Seoul 136-701, Korea Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892-2281, United States

Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

The invention relates to an efficient terrain data loading method for airborne equipment. The method includes such steps as: 1.1, determining longitude-latitude range of terrain data to be extracted, partitioning the terrain data in the longitude-latitude range according to physical location of the terrain data, and logically numbering each data block; 1.2, determining the size of terrain data storage space according to the terrain data to be extracted; 1.3, creating data storage space, corresponding to the terrain data storage space, in memory space, dividing the data storage space, logically numbering the divided data storage space, mapping the data storage space to the physical location of the terrain data. The data in mass physical memory is not required, so that CPU usage is greatly decreased and efficiency in processing the terrain data is improved.

Efficient terrain data loading method for airborne equipment

Microring resonator-coupled Mach-Zehnder interferometer (MRCMZI) is attractive for its applications in the field of
all-optical switch, with low threshold, fast response speed and compact scale suitable for integration. The paper provides
analytically and numerically investigation on optical pulse transmission characteristics of MRCMZI. The analytical
formulations of dynamic process are derived in an easy-understood method of light beam tracing. These formulations
can degenerate gradually to steady-state response when incident pulse becomes quasi-continuous wave (CW) or
adequately broad with duration much more than cavity lifetime. For the coupled-microresonator system, several
interesting signal processing tasks, such as optical differentiation, integration, pulse compression and trigger pulse
generation, can be realized. Because of the complementarity between two output ports of MZI, the optical pulse
differentiation and integration operations can be carried out synchronously at two output ports through optical
interference between the reference light of direct-bus and the modulated light of coupled-microresonator bus. The
interesting functions related to optical pulse shaping have potential applications in future all-optical communication.

Microring resonator-coupled Mach-Zehnder interferometer as trigger pulse generator, optical differentiator, and integrator

To date, color-tunable photon upconversion (UC) in a single nanocrystal (NC) still suffers from cumbersome structures. Herein, we prepared a compact two-layer NC with bright and high-purity red and green UC emission upon 980 and 1530 nm excitation, respectively. The effects of trace Tm3+ doping and inert-shell coating on the UC color and intensity were discussed. In addition, the color tuning via various dual-excitation configurations and the color stability with temperature and excitation intensity were demonstrated. The proposed UC NC, featuring compact structure and high-quality color tuning, can lower the synthesis time cost and difficulty of its kind and can find wide applications in multi-channel imaging, display devices, anti-counterfeiting, and so on.

Color tuning in a compact core-shell nanocrystal based on intense and high-purity green and red photon upconversion

Longan (Dimocarpus longan Lour.), as a kind of commercial fruit tree in the family Sapindaceae, is widely cultivated in South Asia. In this study, we obtained the complete chloroplast genome sequen...

Characterization of the complete chloroplast genome of longan (Dimocarpus longan Lour.) using illumina paired-end sequencing.

A two-core hollow optical fiber for a polarizer based on surface plasmon resonance (SPR) is proposed and studied by the full-vector finite-element method. The proposed fiber consists of two circular cores, inner cladding, outer cladding, and a large central air hole. The two cores are arranged symmetrically in inner cladding and couple weakly with the air hole. There is no cross talk between cores because they are insulated by the air hole. A nanodimension Ag/Au bimetallic layer can be coated on the inner surface of the central air hole to support SPR. The numerical results show that single polarization of two cores is achieved simultaneously at the wavelength of 1.310 μm, due to strong coupling between the TM mode and the surface plasmon polariton mode. The extinction ratio 40.90 dB with 3 mm length is obtained, and the confinement loss of TE mode is 0.19 dB/cm. Moreover, the resonance wavelength is tunable by varying the refractive index of materials in the central air hole. The scheme is helpful for coupling an all-fiber polarizer with multicore polarization maintaining fibres (PMFs) and makes possible application in in-fiber integrated interferometric sensors while maintaining polarization.

Li Li

Papers

Efficient terrain data loading method for airborne equipment

Microring resonator-coupled Mach-Zehnder interferometer as trigger pulse generator, optical differentiator, and integrator

Color tuning in a compact core-shell nanocrystal based on intense and high-purity green and red photon upconversion

Characterization of the complete chloroplast genome of longan (Dimocarpus longan Lour.) using illumina paired-end sequencing.

Two-core single-polarization optical fiber with a large hollow coated bimetallic layer.