L
Li Li
Researcher at Johns Hopkins University School of Medicine
Publications - 82
Citations - 2447
Li Li is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 25, co-authored 69 publications receiving 2085 citations. Previous affiliations of Li Li include Johns Hopkins University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression
TL;DR: Investigation of the mechanism by which internal tandem duplication (ITD) mutation of FLT3 signaling blocks differentiation finds that forced expression of C/EBPalpha was able to overcomeFLT3/ITD-mediated differentiation block, further proving the importance of C- EBPalpha in this process.
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A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications
Zhi Sheng,Li Li,Lihua Julie Zhu,Thomas W. Smith,Andrea Demers,Alonzo H. Ross,Richard P. Moser,Michael R. Green +7 more
TL;DR: The results reveal an essential survival pathway in malignant glioma, whereby activation of a RAS–mitogen-activated protein kinase or phosphoinositide-3-kinase signaling cascade leads to induction of the transcription factor cAMP response element–binding protein-3–like-2 (CREB3L2), which directly activates ATF5 expression.
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Internal tandem duplications of the FLT3 gene are present in leukemia stem cells
Mark J. Levis,Kathleen M. Murphy,Rosalyn Pham,Kyu-Tae Kim,Adam Stine,Li Li,Ian McNiece,B. Douglas Smith,Donald Small +8 more
TL;DR: It is established that the FLT3/ITD mutations are present in leukemia stem cells, and thatFLT3 inhibitors may have activity against these cells.
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Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.
Li Li,Obdulio Piloto,Ho Bao Nguyen,Kathleen Greenberg,Kogo Takamiya,Frederick Racke,David L. Huso,Donald Small,Donald Small +8 more
TL;DR: expression of FLT3/ITD mutations alone is capable of conferring normal hematopoietic stem/progenitor cells (HSPCs) with enhanced myeloid expansion and appears to suppress B lymphoid maturation.
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PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation.
Li Li,Fenghua Liu,Rebecca Salmonsen,Tod K. Turner,N. Scott Litofsky,Antonio Di Cristofano,Pier Paolo Pandolfi,Stephen N. Jones,Lawrence Recht,Alonzo H. Ross +9 more
TL;DR: Observations indicate that PTEN regulates SVZ precursor cell function and is particularly important for migration and apoptosis in response to oxidative stress.