L
Lianbo Yu
Researcher at Ohio State University
Publications - 136
Citations - 7609
Lianbo Yu is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Medicine. The author has an hindex of 33, co-authored 113 publications receiving 5975 citations. Previous affiliations of Lianbo Yu include The Ohio State University Wexner Medical Center.
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Journal ArticleDOI
Detection of microRNA Expression in Human Peripheral Blood Microvesicles
Melissa Piper Hunter,Noura Ismail,Noura Ismail,Xiaoli Zhang,Baltazar D. Aguda,Eun Joo Lee,Lianbo Yu,Tao Xiao,Jeffrey Schafer,Mei-Ling Ting Lee,Thomas D. Schmittgen,S. Patrick Nana-Sinkam,David Jarjoura,Clay B. Marsh,Clay B. Marsh +14 more
TL;DR: This study is the first to identify and define miRNA expression in circulating plasma microvesicles of normal subjects, and provides a basis for future studies to determine the predictive role of peripheral blood miRNA signatures in human disease.
Journal ArticleDOI
Landscape of Microsatellite Instability Across 39 Cancer Types.
Russell Bonneville,Melanie A. Krook,Esko A. Kautto,Jharna Miya,Michele R. Wing,Hui-Zi Chen,Julie W. Reeser,Lianbo Yu,Sameek Roychowdhury +8 more
TL;DR: Evidence of as-yet-unappreciated MSI in several types of cancer support an expanded role for clinical MSI testing across multiple cancer types as patients with MSI-positive tumors are predicted to benefit from novel immunotherapies in clinical trials.
Journal ArticleDOI
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
Shu-Hao Hsu,Bo Wang,Janaiah Kota,Jianhua Yu,Stefan Costinean,Huban Kutay,Lianbo Yu,Shoumei Bai,Shoumei Bai,Krista M. D. La Perle,Raghu R. Chivukula,Hsiaoyin Mao,Min Wei,K. Reed Clark,K. Reed Clark,Jerry R. Mendell,Jerry R. Mendell,Michael A. Caligiuri,Samson T. Jacob,Joshua T. Mendell,Kalpana Ghoshal +20 more
TL;DR: It is demonstrated that deletion of mouse Mir122 resulted in hepatosteatosis, hepatitis, and the development of tumors resembling HCC, demonstrating critical functions for miR-122 in the maintenance of liver homeostasis and have important therapeutic implications, including the potential utility of mi R-122 delivery for selected patients with HCC and the need for careful monitoring of patients receiving miR -122 inhibition therapy for HCV.
Journal ArticleDOI
IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer
Thomas A. Mace,Reena Shakya,Jason R. Pitarresi,Benjamin Swanson,Christopher McQuinn,Shannon Loftus,Emily Nordquist,Zobeida Cruz-Monserrate,Lianbo Yu,Gregory S. Young,Xiaoling Zhong,Teresa A. Zimmers,Michael C. Ostrowski,Thomas Ludwig,Mark Bloomston,Tanios Bekaii-Saab,Gregory B. Lesinski +16 more
TL;DR: Preclinical results indicate that targeted inhibition of IL-6 may enhance the efficacy of anti-PD-L1 in PDAC, and improve overall survival in KPC-Brca2 mice.
Journal ArticleDOI
Gene expression networks in COPD: microRNA and mRNA regulation.
Michael E. Ezzie,Melissa Crawford,Ji-Hoon Cho,Robert C Orellana,Shile Zhang,Richard Gelinas,Kara Batte,Lianbo Yu,Gerard J. Nuovo,David J. Galas,Philip T. Diaz,Kai Wang,S. Patrick Nana-Sinkam +12 more
TL;DR: In this article, the authors examined miRNA and mRNA expression profiles enriched for biological pathways that may be relevant to the pathogenesis of COPD including the transforming growth factor β, Wnt and focal adhesion pathways.