L
Libin Liu
Researcher at Boston University
Publications - 27
Citations - 2107
Libin Liu is an academic researcher from Boston University. The author has contributed to research in topics: Caveolae & Cavin. The author has an hindex of 18, co-authored 25 publications receiving 1924 citations. Previous affiliations of Libin Liu include Gunma University & Joslin Diabetes Center.
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Journal ArticleDOI
Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance.
Libin Liu,Dennis Brown,Mary McKee,Nathan K. LeBrasseur,Dan Yang,Kenneth H. Albrecht,Katya Ravid,Paul F. Pilch +7 more
TL;DR: It is shown by means of targeted gene disruption in mice that a distinct caveolae-associated protein, Cavin/PTRF, is an essential component of caveolai formation and underscores the multiorgan role of Caveolae in metabolic regulation and the obligate presence of Cavin for caveolAE formation.
Journal ArticleDOI
A Critical Role of Cavin (Polymerase I and Transcript Release Factor) in Caveolae Formation and Organization
Libin Liu,Paul F. Pilch +1 more
TL;DR: It is proposed that the presence of cavin on the inside surface of caveolae stabilizes these structures, probably through interaction with the cytoskeleton, and cavin therefore plays an important role in Caveolae formation and organization.
Journal ArticleDOI
Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells
Mark T. Howes,Matthew Kirkham,James D. Riches,Katia Cortese,Piers J. Walser,Fiona Simpson,Michelle M. Hill,Alun Jones,Richard Lundmark,Margaret R. Lindsay,Delia J. Hernández-Deviez,Gordana Hadzic,Adam McCluskey,Rumasia Bashir,Libin Liu,Paul F. Pilch,Harvey T. McMahon,Phillip J. Robinson,John F. Hancock,Satyajit Mayor,Robert G. Parton +20 more
TL;DR: Quantitative ultrastructural analysis and proteomics detail CLIC structure, composition, and function.
Journal ArticleDOI
MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes
Michele Bastiani,Libin Liu,Michelle M. Hill,Mark P. Jedrychowski,Susan J. Nixon,Harriet P. Lo,Daniel Abankwa,Robert Luetterforst,Manuel A. Fernandez-Rojo,Michael R. Breen,Steven P. Gygi,Jørgen Vinten,Piers J. Walser,Kathryn N. North,John F. Hancock,Paul F. Pilch,Robert G. Parton +16 more
TL;DR: Cavin-4 is expressed predominantly in muscle, and its distribution is perturbed in human muscle disease associated with Caveolin-3 dysfunction, identifying Cavin-4 as a novel muscle disease candidate caveolar protein.
Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells
Mark T. Howes,Matthew Kirkham,James D. Riches,Katia Cortese,Piers J. Walser,Fiona Simpson,Michelle M. Hill,Alun Jones,Richard Lundmark,Margaret R. Lindsay,Delia J. Hernández-Deviez,Gordana Hadzic,Adam McCluskey,Rumasia Bashir,Libin Liu,Paul F. Pilch,Harvey T. McMahon,Phillip J. Robinson,John F. Hancock,Satyajit Mayor,Robert G. Parton +20 more
TL;DR: In this article, the authors provided the first quantitative ultrastructural analysis and molecular characterization of the major endocytic pathway in fibroblasts, a pathway that provides rapid membrane turnover at the leading edge of migrating cells.