Lidia M. Duncan

TL;DR: It is shown that modification of K3‐associated class I by lysine‐63‐linked polyubiquitin chains is necessary for their efficient endocytosis and endolysosomal degradation and three lines of evidence that monoubiquitination of class I molecules provides an inefficient internalisation signal are presented.

TL;DR: It is suggested that CD40 is critical in microbial HSP70 binding and stimulation of RANTES production and coimmunoprecipitation of Mtb HSP 70 with CD40 indicates a physical association between these molecules.

TL;DR: The results suggest that JAM-2 is a novel vascular molecule, which participates in interendothelial junctional complexes, and the role of the protein in the sealing of cell-cell contact is suggested.

TL;DR: The results suggest a mechanism by which the KK3‐induced class I ubiquitylation provides a signal for both internalization and sorting to the late endosomal pathway for degradation, which is the first viral gene product that subverts the trafficking of a host protein via the ubiquitin‐dependent endosome sorting machinery.