Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.
Bo Meng,Steven Kemp,Steven Kemp,Guido Papa,Rawlings Datir,Isabella Ferreira,Sara Marelli,William T. Harvey,Spyros Lytras,Ahmed Mohamed,Giulia Gallo,Nazia Thakur,Dami A. Collier,Dami A. Collier,Petra Mlcochova,Lidia M. Duncan,Alessandro M Carabelli,Julia C. Kenyon,Julia C. Kenyon,Andrew M. L. Lever,Andrew M. L. Lever,Anna De Marco,Christian Saliba,Katja Culap,Elisabetta Cameroni,Nicholas J Matheson,Nicholas J Matheson,Luca Piccoli,Davide Corti,Leo C. James,David Robertson,Dalan Bailey,Ravindra K. Gupta +32 more
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This article is published in Cell Reports.The article was published on 2021-06-29 and is currently open access. It has received 307 citations till now. The article focuses on the topics: Infectivity.read more
Citations
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SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
Petra Mlcochova,Steven Kemp,Steven Kemp,Mahesh Shanker Dhar,Guido Papa,Bo Meng,Isabella Ferreira,Rawlings Datir,Dami A. Collier,Dami A. Collier,Anna Albecka,Sujeet Kumar Singh,Rajesh Pandey,Jonathan Brown,Jie Zhou,Niluka Goonawardane,Swapnil Mishra,Charles Whittaker,Thomas A. Mellan,Robin Marwal,Meena Datta,Shantanu Sengupta,Kalaiarasan Ponnusamy,V. S. Radhakrishnan,Adam Abdullahi,Oscar Charles,Partha Chattopadhyay,Priti Devi,Daniela Caputo,Thomas P. Peacock,Chand Wattal,Neeraj Goel,Ambrish Satwik,Raju Vaishya,Meenakshi Agarwal,Antranik Mavousian,Joo-Hyeon Lee,Jessica Bassi,Chiara Silacci-Fegni,Christian Saliba,Dora Pinto,Takashi Irie,Isao Yoshida,William L Hamilton,Kei Sato,Samir Bhatt,Samir Bhatt,Seth Flaxman,Leo C. James,Davide Corti,Luca Piccoli,Wendy S. Barclay,Partha Rakshit,Anurag Agrawal,Ravindra K. Gupta +54 more
TL;DR: The B.617.1.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike as discussed by the authors.
Journal ArticleDOI
The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic
xing feng,Etienne-Emile Baulieu +1 more
TL;DR: In this paper , the authors reported that the Omicron spike was resistant against most therapeutic antibodies but remained susceptible to inhibition by sotrovimab, and that double immunization with BNT162b2 might not adequately protect against severe disease induced by this variant.
Journal ArticleDOI
The biological and clinical significance of emerging SARS-CoV-2 variants.
Kaiming Tao,Philip L Tzou,Janin Nouhin,Ravindra K. Gupta,Tulio de Oliveira,Sergei L Kosakovsky Pond,Daniela Fera,Robert W. Shafer +7 more
TL;DR: The emergence of SARS-CoV-2 variants with novel spike protein mutations that are influencing the epidemiological and clinical aspects of the COVID-19 pandemic has been witnessed as mentioned in this paper.
Journal ArticleDOI
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
Bo Meng,Adam Abdullahi,Isabella Ferreira,Niluka Goonawardane,Akatsuki Saito,Izumi Kimura,Daichi Yamasoba,P. P. G. Gerber,Saman Fatihi,Surabhi Rathore,Samantha K. Zepeda,Guido Papa,Steven Kemp,Terumasa Ikeda,Mako Toyoda,Toong Seng Tan,Jin Kuramochi,Shigeki Mitsunaga,Takamasa Ueno,Kotaro Shirakawa,Akifumi Takaori-Kondo,Teresa Brevini,Donna L. Mallery,Oscar Charles,Stephen Baker,Gordon Dougan,Christoph Hess,Nathalie Kingston,Paul J. Lehner,Paul A. Lyons,Nick Matheson,Willem H. Ouwehand,Caroline M. Saunders,Charlotte Summers,James Thaventhiran,Mark Toshner,Michael P. Weekes,Patrick Maxwell,Ashley Shaw,Ashlea Bucke,Jo Calder,Laura Canna,Jason Domingo,Anne Elmer,Stewart Fuller,Julie Harris,Sarah Hewitt,Jane Kennet,Sherly Jose,Jenny Kourampa,Anne Meadows,Criona O’Brien,Jane Mary Price,Cherry Publico,Rebecca Rastall,Carla Ribeiro,Jane Rowlands,Valentina Ruffolo,Hugo Tordesillas,Ben Bullman,Benjamin J. Dunmore,Stefan Gräf,Joshua Hodgson,Christopher Huang,K Hunter,Emma Jones,Ekaterina Legchenko,Cecilia Cabrera Matara,Jennifer M. Martin,Federica Mescia,Ciara O’Donnell,Linda Pointon,Joy Shih,Rachel Sutcliffe,Tobias Tilly,Carmen M. Treacy,Zhen Tong,Jennifer Wood,Marta Wylot,Ariana Betancourt,Georgie Bower,Chiara Cossetti,Aloka De Sa,Maddie Epping,Stuart Fawke,Nicholas Gleadall,Richard Grenfell,Andrew Hinch,Sarah Jackson,Isobel Jarvis,Ben Krishna,Francesca L. Nice,Ommar Omarjee,Marianne Perera,Martin Potts,Nathan Richoz,Veronika Romashova,Luca Stefanucci,Mateusz Strezlecki,Lori Turner,E. D. De Bie,Katherine Bunclark,Masa Josipovic,Michael Mackay,Helen Butcher,Dan Scott Caputo,Mathew Allen. Chandler,Patrick F. Chinnery,Debbie Clapham-Riley,E Dewhurst,Christian Fernandez,Anita Furlong,Barbara J. Graves,J. Gray,Sabine Hein,Tasmin Ivers,Emma Le Gresley,Rachel Linger,Mary A Kasanicki,Rebecca King,Sara E. Meloy,Alex A. Moulton,Frances E. Muldoon,Nigel R. Ovington,Sofia Papadia,Christopher J. Penkett,Isabel Phelan,Venkatesh-Prasad Ranganath,R. Paraschiv,Abigail Sage,Jennifer G. Sambrook,Ingrid Scholtes,Katherine Schon,Hannah Stark,Kathleen Stirrups,Paul Townsend,Neil Walker,Jennifer Rose Webster,Erika P. Butlertanaka,Yurie Tanaka,Jumpei Ito,Keiya Uriu,Yusuke Kosugi,Mai Suganami,Akiko Oide,Miyabishara Yokoyama,Mika Chiba,Chihiro Motozono,Hesham Nasser,Ryo Shimizu,K. Kitazato,Haruyo Hasebe,Takashi Irie,So Nakagawa,Jiaqi Wu,Miyoko Takahashi,Takasuke Fukuhara,Kenta Shimizu,Kana Tsushima,Haruko Kubo,Yasuhiro Kazuma,Ryosuke Nomura,Yoshihito Horisawa,Kayoko Nagata,Yugo Kawai,Yohei Yanagida,Yusuke Tashiro,Kenzo Tokunaga,Seiya Ozono,Ryoko Kawabata,Nanami Morizako,Kenji Sadamasu,Hiroyuki Asakura,Mami Nagashima,Kazuhisa Yoshimura,Paul Cardenas,E. Muñoz,Veronica Barragan,Sully Márquez,Belén Prado-Vivar,Mónica Becerra-Wong,Mateo Caravajal,Gabriel Trueba,Patricio Rojas-Silva,Michelle Grunauer,Bernardo Gutierrez,Juan José Guadalupe,Juan Carlos Fernandez-Cadena,D. Andrade-Molina,Manuel E. Baldeón,Andrea Pinos,John E. Bowen,Anshu Joshi,Alexandra C. Walls,Laurelle Jackson,Darren Martin,Kenneth G. C. Smith,John S. Bradley,John A. G. Briggs,Jin W. Choi,Elo Madissoon,Kerstin B. Meyer,Petra Mlcochova,Lourdes Ceron-Gutierrez,Rainer Doffinger,Sarah A. Teichmann,Andrew J. Fisher,Matteo Samuele Pizzuto,Anna De Marco,Davide Corti,Myra Hosmillo,Joo-Hyeon Lee,Leo C. James,Lipi Thukral,David Veesler,Alex Sigal,Fotios Sampaziotis,Ian Goodfellow,Kei Sato,Ravindra K. Gupta +219 more
TL;DR: The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein this paper , which increased the evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses.
Journal ArticleDOI
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
Bo Meng,Adam Abdullahi,Isabella Ferreira,Niluka Goonawardane,Akatsuki Saito,Izumi Kimura,Daichi Yamasoba,P. P. G. Gerber,Saman Fatihi,Surabhi Rathore,Samantha K. Zepeda,Guido Papa,Steven Kemp,Terumasa Ikeda,Mako Toyoda,Toong Seng Tan,Jin Kuramochi,Shigeki Mitsunaga,Takamasa Ueno,Kotaro Shirakawa,Akifumi Takaori-Kondo,Teresa Brevini,Donna L. Mallery,Oscar Charles,John E. Bowen,Anshu Joshi,Alexandra C. Walls,Laurelle Jackson,Darren Martin,Ken C. Smith,John S. Bradley,John A. G. Briggs,Jin W. Choi,Elo Madissoon,Kerstin Meyer,Petra Mlcochova,Lourdes Ceron-Gutierrez,Rainer Doffinger,Sarah A. Teichmann,Andrew J. Fisher,Matteo Samuele Pizzuto,Anna De Marco,Davide Corti,Myra Hosmillo,Joo-Hyeon Lee,Leo C. James,Lipi Thukral,David Veesler,Alex Sigal,Fotios Sampaziotis,Ian Goodfellow,Nick Matheson,Kei Sato,Ravindra K. Gupta,The CITIID-NIHR BioResource COVID-19 Collaboration,The Genotype to Phenotype Japan Consortium,Ecuador-COVID19 Consortium +56 more
TL;DR: In this article , the SARS-CoV-2 Omicron BA has multiple mutations in its spike protein, which increases evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses.
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Kazutaka Katoh,Daron M. Standley +1 more
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Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor.
Jun Lan,Jiwan Ge,Jinfang Yu,Sisi Shan,Huan Zhou,Shilong Fan,Qi Zhang,Xuanling Shi,Qisheng Wang,Linqi Zhang,Xinquan Wang +10 more
TL;DR: High-resolution crystal structures of the receptor-binding domain of the spike protein of SARS-CoV-2 and SARS -CoV in complex with ACE2 provide insights into the binding mode of these coronaviruses and highlight essential ACE2-interacting residues.
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