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Alexsandra Espejo
Researcher at University of Texas MD Anderson Cancer Center
Publications - 28
Citations - 3204
Alexsandra Espejo is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Histone methyltransferase & Methylation. The author has an hindex of 18, co-authored 25 publications receiving 2948 citations.
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Journal ArticleDOI
p53 is regulated by the lysine demethylase LSD1
Jing Huang,Roopsha Sengupta,Alexsandra Espejo,Min Gyu Lee,Jean Dorsey,Mario Richter,Susanne Opravil,Ramin Shiekhattar,Mark T. Bedford,Thomas Jenuwein,Shelley L. Berger +10 more
TL;DR: Lysine methylation provides similar regulatory complexity for non-histone proteins and for histones and that the methylation status at a single lysine residue confers distinct regulatory output.
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Tudor, MBT and chromo domains gauge the degree of lysine methylation
Jeesun Kim,Jeremy J. Daniel,Alexsandra Espejo,Aimee Lake,Murli Krishna,Li Xia,Yi Zhang,Mark T. Bedford +7 more
TL;DR: These studies expose tudor and MBT domains as new classes of methyl‐lysine‐binding protein modules, and demonstrates that protein‐domain microarrays are powerful tools for the identification of new domain types that recognize histone modifications.
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A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
Gunnar Schotta,Roopsha Sengupta,Roopsha Sengupta,Stefan Kubicek,Stephen Malin,Monika Kauer,Elsa Callen,Arkady Celeste,Michaela Pagani,Susanne Opravil,Inti A. De La Rosa-Velázquez,Alexsandra Espejo,Mark T. Bedford,André Nussenzweig,Meinrad Busslinger,Thomas Jenuwein +15 more
TL;DR: Conversion to an H4K20me1 state results in compromised chromatin that is insufficient to protect genome integrity and to process a DNA-rearranging differentiation program in the mouse.
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Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling
Dan Levy,Alex J. Kuo,Uwe Schaefer,Christopher Kitson,Peggie Cheung,Alexsandra Espejo,Barry M. Zee,Chih Long Liu,Stephanie Tangsombatvisit,Ruth I. Tennen,Andrew Kuo,Song Tanjing,Regina Cheung,Katrin F. Chua,Katrin F. Chua,Paul J. Utz,Xiaobing Shi,Rab K. Prinjha,Kevin Lee,Benjamin A. Garcia,Mark T. Bedford,Alexander Tarakhovsky,Xiaodong Cheng,Or Gozani +23 more
TL;DR: The findings establish a previously uncharacterized mechanism by which chromatin signaling regulates inflammation programs, and identify SETD6 as a methyltransferase that monomethylated chromatin-associated transcription factor NF-κB subunit RelA at Lys310 (RelAK310me1).
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TDRD3 is an Effector Molecule for Arginine Methylated Histone Marks
TL;DR: TDRD3 is an effector molecule that promotes transcription by binding methylarginine marks on histone tails by using a protein domain microarray approach to identify it as a "reader" of these marks.