L
Lijun Shang
Researcher at London Metropolitan University
Publications - 45
Citations - 755
Lijun Shang is an academic researcher from London Metropolitan University. The author has contributed to research in topics: Gating & Chemical warfare. The author has an hindex of 13, co-authored 39 publications receiving 573 citations. Previous affiliations of Lijun Shang include University of Bradford & Fourth Military Medical University.
Papers
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Journal ArticleDOI
Functional analysis of missense variants in the TRESK ( KCNK18 ) K + channel
Isabelle Andres-Enguix,Lijun Shang,Phillip J. Stansfeld,Julia M. Morahan,Mark S.P. Sansom,Ronald G. Lafrenière,Bishakha Roy,Lyn R. Griffiths,Guy A. Rouleau,George C. Ebers,Zameel M. Cader,Stephen J. Tucker +11 more
TL;DR: The functional characterisation of additional TRESK channel missense variants identified in unrelated patients indicates that a single non-functional TResK variant is not alone sufficient to cause typical migraine and highlights the genetic complexity of this disorder.
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Advances in antitumor effects of NSAIDs.
TL;DR: The progress of the application of NSAIDs, especially aspirin, in the prevention and treatment of tumors in recent years is summarized, and new ideas and directions for the follow-up study are also discussed.
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H Bonding at the Helix-Bundle Crossing Controls Gating in Kir Potassium Channels
Markus Rapedius,Philip W. Fowler,Lijun Shang,Mark S.P. Sansom,Stephen J. Tucker,Thomas Baukrowitz +5 more
TL;DR: It is demonstrated that H+ and PIP2 use a conserved gating mechanism defined by similar structural changes in the transmembrane (TM) helices and the selectivity filter, which defines a common gating motif in the Kir channel superfamily.
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Alterations in intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in human endothelial cells.
Khaled Habas,Lijun Shang +1 more
TL;DR: The results showed that administration of 100μM of H2O2 on HUVECs for 2, 6, 12 and 24’h induced a time-dependent increase in ICAM-1 and VCAM- 1 mRNA and protein expression levels with a significant increase observed from 6 h, suggesting that H2 O2 induced oxidative stress may be a reasonable for atherosclerosis.
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Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel
Markus Rapedius,Shozeb Haider,Katharine F Browne,Lijun Shang,Mark S.P. Sansom,Thomas Baukrowitz,Stephen J. Tucker +6 more
TL;DR: It is demonstrated that instead of interacting with K80, the RKR arginine residues form highly conserved inter‐ and intra‐subunit interactions that are important for Kir channel gating and influence pH sensitivity indirectly.