Advances in antitumor effects of NSAIDs.
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TLDR
The progress of the application of NSAIDs, especially aspirin, in the prevention and treatment of tumors in recent years is summarized, and new ideas and directions for the follow-up study are also discussed.Abstract:
In recent years, the reports on using nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer prevention and treatment have been on the rise. In 2017, the US Preventive Services Working Group issued primary prevention guidelines on the use of NSAIDs, especially aspirin, for cardiovascular disease and colorectal cancer, and formally established the role and status of aspirin in cancer prevention. However, the mechanism of NSAIDs on preventing cancer is still not clear. In this paper, the progress of the application of NSAIDs, especially aspirin, in the prevention and treatment of tumors in recent years is summarized, and new ideas and directions for the follow-up study are also discussed.read more
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Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective.
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Main Inflammatory Cells and Potentials of Anti-Inflammatory Agents in Prostate Cancer.
TL;DR: E Epidemiological investigations and basic research using human immune cells or mouse models have revealed that non-steroidal anti-inflammatory drugs, metformin, statins, soy isoflavones, and other diets are potential interventions for preventing progression of prostate cancer by suppressing inflammation.
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Amending microbiota by targeting intestinal inflammation with TNF blockade attenuates development of colorectal cancer.
TL;DR: The role of microbiota is established in mediating the antitumorigenic effect of anti-tumor necrosis factor (TNF) therapy and microbiota transplantation showed reduced carcinogenic activity of microbiota from anti-TNF-treated mice, demonstrating the plasticity of microbiota, which could be reverted to noncarcinogenic status by targeting inflammation.
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Peter M. Rothwell,M Wilson,Carl-Eric Elwin,Bo Norrving,Ale Algra,Charles P Warlow,Tom W. Meade +6 more
TL;DR: Benefit was greatest for cancers of the proximal colon, which are not otherwise prevented effectively by screening with sigmoidoscopy or colonoscopy, and benefit increased with scheduled duration of treatment.
Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
TL;DR: In this article, platelet-tumor cell interactions are sufficient to prime tumor cells for subsequent metastasis, resulting in an invasive mesenchymal-like phenotype and enhanced metastasis in vivo.
Journal ArticleDOI
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