L
Lilyann Novak-Frazer
Researcher at University of Manchester
Publications - 13
Citations - 304
Lilyann Novak-Frazer is an academic researcher from University of Manchester. The author has contributed to research in topics: Aspergillus fumigatus & Biofilm. The author has an hindex of 8, co-authored 13 publications receiving 190 citations. Previous affiliations of Lilyann Novak-Frazer include Manchester Academic Health Science Centre & University Hospital of South Manchester NHS Foundation Trust.
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Journal ArticleDOI
Chronic Pulmonary Aspergillosis-Where Are We? and Where Are We Going?
Gemma Hayes,Lilyann Novak-Frazer +1 more
TL;DR: Current knowledge and practices are reviewed, and areas of research priority highlighted, with the development of new therapies being a key priority.
Journal ArticleDOI
2-hydroxyisocaproic acid is fungicidal for Candida and Aspergillus species.
M. Sakko,M. Sakko,Caroline B. Moore,Lilyann Novak-Frazer,V. Rautemaa,Timo Sorsa,P. Hietala,Asko Järvinen,Paul Bowyer,Leo Tjäderhane,Leo Tjäderhane,Leo Tjäderhane,Riina Rautemaa +12 more
TL;DR: HICA has broad antifungal activity against Candida and Aspergillus at concentrations relevant for topical therapy, and may be useful in the topical treatment of multispecies superficial infections.
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Validation of biofilm formation on human skin wound models and demonstration of clinically translatable bacteria-specific volatile signatures
Mohammed Ashrafi,Lilyann Novak-Frazer,Lilyann Novak-Frazer,Matthew Bates,Mohamed Baguneid,Teresa A Alonso-Rasgado,Guoqing Xia,Riina Rautemaa-Richardson,Riina Rautemaa-Richardson,Ardeshir Bayat +9 more
TL;DR: These models provide a vehicle for human skin-relevant biofilm studies and VOC detection has potential clinical translatability in efficient non-invasive diagnosis of wound infection.
Journal ArticleDOI
Lung colonization by Aspergillus fumigatus is controlled by ZNF77
Sara Gago,Nicola L. D. Overton,Nagwa Ben-Ghazzi,Lilyann Novak-Frazer,Lilyann Novak-Frazer,Nick D. Read,David W. Denning,Paul Bowyer +7 more
TL;DR: In this article, the authors used genome-edited epithelial cells to show that the genetic variant rs35699176 in ZNF77 causes loss of integrity of the bronchial epithelium and increases levels of extracellular matrix proteins.
Journal ArticleDOI
Reactive Oxygen: a novel antimicrobial mechanism for targeting biofilm-associated infection
Matthew Dryden,Matthew Dryden,Jonathan Cooke,Rami J. Salib,Rebecca E. Holding,T.C. Biggs,Ali A. Salamat,Raymond N. Allan,Rachel S. Newby,Fenella D. Halstead,B. Oppenheim,Thomas J. Hall,Sophie C. Cox,Liam M. Grover,Zain Al-hindi,Lilyann Novak-Frazer,Malcolm Richardson +16 more
TL;DR: Reactive oxygen species has been successful in treating chronic wounds and in clearing multidrug-resistant organisms, including methicillin-resistant Staphylococcus aureus, and carbapenemase-producing isolates from wounds and vascular line sites.