L
Lin Chen
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 31
Citations - 7597
Lin Chen is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Plasmodium falciparum & Bcl-2 Homologous Antagonist-Killer Protein. The author has an hindex of 25, co-authored 30 publications receiving 7214 citations. Previous affiliations of Lin Chen include University of Melbourne.
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Journal ArticleDOI
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
Lin Chen,Simon N. Willis,Andrew H. Wei,Brian J. Smith,Jamie I. Fletcher,Mark G. Hinds,Peter M. Colman,Catherine L. Day,Jerry M. Adams,David C.S. Huang +9 more
TL;DR: The results suggest that apoptosis relies on selective interactions between particular subsets of these proteins and that it should be feasible to discover BH3-mimetic drugs that inactivate specific prosurvival targets.
Journal ArticleDOI
Proapoptotic Bak Is Sequestered by Mcl-1 and Bcl-xL, but Not Bcl-2, Until Displaced by BH3-only Proteins
Simon N. Willis,Lin Chen,Grant Dewson,Andrew H. Wei,Edwina Naik,Jamie I. Fletcher,Jerry M. Adams,David C.S. Huang +7 more
TL;DR: The results indicate that Bak is held in check solely by Mcl-1 and Bcl-x(L) and induces apoptosis only if freed from both, and the finding that different prosurvival proteins have selective roles has notable implications for the design of anti-cancer drugs that target the B cl-2 family.
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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
Mark F. van Delft,Andrew H. Wei,Kylie D. Mason,Kylie D. Mason,Cassandra J. Vandenberg,Lin Chen,Peter E. Czabotar,Simon N. Willis,Clare L. Scott,Catherine L. Day,Suzanne Cory,Jerry M. Adams,Andrew W. Roberts,David C.S. Huang +13 more
TL;DR: It is shown that resistance reflects ABT-737's inability to target another prosurvival relative, Mcl-1, and should prove efficacious in tumors with low MCl-1 levels, or when combined with agents that inactivate Mcl -1, even to treat those tumors that overexpress Bcl-2.
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Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
Simon N. Willis,Jamie I. Fletcher,Thomas Kaufmann,Mark F. van Delft,Mark F. van Delft,Lin Chen,Peter E. Czabotar,Helen Ierino,Erinna F. Lee,Erinna F. Lee,W. Douglas Fairlie,Philippe Bouillet,Andreas Strasser,Ruth M. Kluck,Jerry M. Adams,David C.S. Huang +15 more
TL;DR: Contrary to the direct-activation model, it is shown that Bax and Bak can mediate apoptosis without discernable association with the putative BH3-only activators (Bim, Bid, and Puma).
Journal ArticleDOI
Reticulocyte-binding protein homologue 5 – An essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum
Jake Baum,Lin Chen,Julie Healer,Sash Lopaticki,Michelle J. Boyle,Tony Triglia,Florian Ehlgen,Stuart A. Ralph,James G. Beeson,Alan F. Cowman +9 more
TL;DR: A further, putatively essential, PfRh family member in the most virulent human malaria Plasmodium falciparum is identified, called PfRh5, which binds to an unknown class of glycosylated receptors on the erythrocyte surface and may prove to be a valuable candidate for inclusion in a multi-component anti-malarial vaccine.