E
Edwina Naik
Researcher at Genentech
Publications - 9
Citations - 2291
Edwina Naik is an academic researcher from Genentech. The author has contributed to research in topics: Apoptosis & Endothelial stem cell. The author has an hindex of 9, co-authored 9 publications receiving 2132 citations. Previous affiliations of Edwina Naik include Walter and Eliza Hall Institute of Medical Research & Cooperative Research Centre.
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Journal ArticleDOI
Proapoptotic Bak Is Sequestered by Mcl-1 and Bcl-xL, but Not Bcl-2, Until Displaced by BH3-only Proteins
Simon N. Willis,Lin Chen,Grant Dewson,Andrew H. Wei,Edwina Naik,Jamie I. Fletcher,Jerry M. Adams,David C.S. Huang +7 more
TL;DR: The results indicate that Bak is held in check solely by Mcl-1 and Bcl-x(L) and induces apoptosis only if freed from both, and the finding that different prosurvival proteins have selective roles has notable implications for the design of anti-cancer drugs that target the B cl-2 family.
Journal ArticleDOI
Mitochondrial reactive oxygen species drive proinflammatory cytokine production
Edwina Naik,Vishva M. Dixit +1 more
TL;DR: Recent work indicates that mitochondrial ROS act via several pathways to elicit proinflammatory cytokines in human and mouse cells and this work is likely to be important for understanding the role of ROS in inflammation.
Journal ArticleDOI
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
TL;DR: Results demonstrate that UVR activates the Bcl-2–regulated apoptotic pathway predominantly through activation of Noxa and, depending on cellular context, Puma.
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Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1.
Kenneth W. Harder,Cathy Quilici,Cathy Quilici,Cathy Quilici,Edwina Naik,Edwina Naik,Edwina Naik,Melissa Inglese,Melissa Inglese,Melissa Inglese,Nicole Kountouri,Nicole Kountouri,Nicole Kountouri,Amanda Turner,Amanda Turner,Amanda Turner,Kristina Zlatic,Kristina Zlatic,Kristina Zlatic,David M. Tarlinton,David M. Tarlinton,David M. Tarlinton,Margaret L. Hibbs,Margaret L. Hibbs,Margaret L. Hibbs +24 more
TL;DR: It is demonstrated that loss of Lyn results in a stem/progenitor cell-intrinsic defect leading to an age-dependent increase in myeloid, erythroid, and primitive hematopoietic progenitor numbers that is independent of autoimmune disease.
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Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X.
TL;DR: It is shown that the deubiquitinating enzyme Usp9X is a regulator of T cell activation and its loss induces the development of a lupuslike autoimmune disease in mice.