S
Stuart A. Ralph
Researcher at University of Melbourne
Publications - 112
Citations - 14923
Stuart A. Ralph is an academic researcher from University of Melbourne. The author has contributed to research in topics: Plasmodium falciparum & Apicoplast. The author has an hindex of 51, co-authored 107 publications receiving 13680 citations. Previous affiliations of Stuart A. Ralph include J. Craig Venter Institute & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
Genome sequence of the human malaria parasite Plasmodium falciparum
Malcolm J. Gardner,Neil Hall,Eula Fung,Owen White,Matthew Berriman,Richard W. Hyman,Jane M. Carlton,Arnab Pain,Karen E. Nelson,Sharen Bowman,Ian T. Paulsen,Keith D. James,Jonathan A. Eisen,Kim Rutherford,Steven L. Salzberg,Alister Craig,Sue Kyes,Man Suen Chan,Vishvanath Nene,Shamira J. Shallom,Bernard B. Suh,Jeremy Peterson,Samuel V. Angiuoli,Mihaela Pertea,Jonathan E. Allen,Jeremy D. Selengut,Daniel H. Haft,Michael W. Mather,Akhil B. Vaidya,David M. A. Martin,Alan H. Fairlamb,Martin Fraunholz,David S. Roos,Stuart A. Ralph,Geoffrey I. McFadden,Leda M. Cummings,G. Mani Subramanian,Christopher J. Mungall,J. Craig Venter,Daniel J. Carucci,Stephen L. Hoffman,Chris I. Newbold,Ronald W. Davis,Claire M. Fraser,Bart Barrell +44 more
TL;DR: The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
Journal ArticleDOI
Comparative genomics of the neglected human malaria parasite Plasmodium vivax
Jane M. Carlton,Jane M. Carlton,John H. Adams,Joana C. Silva,Shelby L. Bidwell,Hernan Lorenzi,Elisabet Caler,Jonathan Crabtree,Jonathan Crabtree,Samuel V. Angiuoli,Emilio F. Merino,Paolo Amedeo,Qin Cheng,Richard M.R. Coulson,Brendan S. Crabb,Hernando A. del Portillo,Kobby Essien,T. Feldblyum,Carmen Fernandez-Becerra,Paul R. Gilson,Amy H. Gueye,Xiang Guo,Simon Kang’a,Taco W. A. Kooij,Michael Korsinczky,Michael Korsinczky,Esmeralda V. S. Meyer,Vish Nene,Ian T. Paulsen,Owen White,Stuart A. Ralph,Qinghu Ren,Tobias Sargeant,Steven L. Salzberg,Christian J. Stoeckert,Steven A. Sullivan,Marcio Massao Yamamoto,Stephen L. Hoffman,Jennifer R. Wortman,Malcolm J. Gardner,Mary R. Galinski,John W. Barnwell,Claire M. Fraser-Liggett +42 more
TL;DR: The synteny and isochore structure of P. vivax chromosomes are described, and it is shown that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously.
Journal ArticleDOI
Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast.
Stuart A. Ralph,Giel G. van Dooren,Ross F. Waller,Michael Crawford,Martin Fraunholz,Bernardo J. Foth,Christopher J. Tonkin,David S. Roos,Geoffrey I. McFadden +8 more
TL;DR: Several anabolic pathways for the parasite plastid are reconstructed that are fundamentally different to the analogous pathways in the human host and are potentially good targets for drug development.
Journal ArticleDOI
Telomeric Heterochromatin Propagation and Histone Acetylation Control Mutually Exclusive Expression of Antigenic Variation Genes in Malaria Parasites
Lucio H. Freitas-Junior,Rosaura Hernández-Rivas,Stuart A. Ralph,Dvorak Montiel-Condado,Omar K. Ruvalcaba-Salazar,Ana Paola Rojas-Meza,Liliana Mâncio-Silva,Ricardo J. Leal-Silvestre,Alisson M. Gontijo,Spencer L. Shorte,Artur Scherf +10 more
TL;DR: The data demonstrate that mutually exclusive transcription of var genes is linked to the dynamic remodeling of chromatin, and this work identifies chromatin modifications at telomeres that spread far into telomere-proximal regions, including var gene loci (>50 kb).
Journal ArticleDOI
Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum
Bernardo J. Foth,Stuart A. Ralph,Christopher J. Tonkin,Nicole S. Struck,Martin Fraunholz,David S. Roos,Alan F. Cowman,Geoffrey I. McFadden +7 more
TL;DR: Altering the specific charge characteristics in a model transit peptides by site-directed mutagenesis severely disrupted organellar targeting in vivo and putative Hsp70 (DnaK) binding sites present in the transit peptide proved to be important for correct targeting.