Showing papers in "Cancer Letters in 1999"

TL;DR: It is found that resveratrol reduces viability and DNA synthesis capability of cultured human promyelocytic leukemia (HL-60) cells and is suggested to have cancer therapeutic as well as chemopreventive potential.

TL;DR: Activation of the cdk inhibitory protein p21 byEllagic acid suggests a role for ellagic acid in cell cycle regulation of cancer cells.

TL;DR: GF120918 appears to fit the paradigm of a multispecific blocker and is able to block rhodamine and mitoxanrone efflux by the newly identified mitoxantrone transporter.

TL;DR: Positive correlations were observed between CYP19 and COX-2 and the greater extent of breast cancer cellularity, suggesting that autocrine and paracrine mechanisms may be involved in hormone-dependent breast cancer development via growth stimulation from local estrogen biosynthesis.

TL;DR: Morphology of liver tissue and levels of marker enzymes indicated that these extracts offered protection against chemical carcinogenesis, as well as levels of carcinogen metabolizing enzymes, levels of liver cancer markers and liver injury markers.

TL;DR: It is suggested that curcumin and catechin inhibit the invasion of B16F-10 melanoma cells by inhibition of metalloproteinases, thereby inhibiting lung metastasis.

TL;DR: It is demonstrated that BHA is an effective inhibitor of BaP plus NNK-induced lung tumorigenesis in A/J mice when administered during the period of carcinogen treatment and that, among the compounds tested, myo-inositol is most effective after carcinogen Treatment.

TL;DR: It is suggested that the cancer chemopreventive and anti-carcinogenic effects of silymarin reported earlier are due to the main constituent silibinin, a flavonoid antioxidant isolated from milk thistle.

TL;DR: Membrane fluidity of non-cultured lung cancer tissue was studied by electron paramagnetic resonance (EPR) and an empirical fluidity parameter (H13) was defined as the criterion to correlate EPR and clinical data.

TL;DR: The results suggest that IH-901 is not cross-resistant to CDDP in this cell line and could be a candidate for the treatment of CDDP resistant pulmonary cancer.

TL;DR: Co-mutagenic beta-carbolines, such as norharman and harman, were quantified in mainstream and sidestream smoke condensates of six Japanese brands of cigarettes, and also in 13 kinds of cooked foods, using a combination of blue cotton treatment and HPLC, suggesting that humans are exposed to norHarman and Harman in daily life to a larger extent than to HCAs.

TL;DR: Results suggest that polynuclear aromatic hydrocarbons from tobacco smoke and other environmental sources can be transported to the cervix where they are metabolized in the cervical epithelium toultimate carcinogenic agents, although transport of ultimate carcinogenic metabolites from other organs toThe cervix cannot be ruled out.

TL;DR: Results provide direct evidence that the contribution of neutrophils, macrophages and T lymphocytes is essential for the maintenance of long-term control of PDT-treated tumors.

TL;DR: Results suggest that Prx I is expected to be a candidate for novel tumor markers to discriminate tissue types of tumors.

TL;DR: It is indicated that GSP possesses anti-tumor promoting activity when applied to CD-1 mouse skin prior to treatment with TPA, and warrants further evaluation as a skin cancer chemopreventative agent.

TL;DR: Using an in vitro model of folate deprivation and repletion, the essentiality of folic acid for de novo nucleotide synthesis and the integrity of the DNA is emphasized.

TL;DR: The data indicate that l-gossypol was significantly more active than cisplatin, melphalan and dacarbazine in the two melanoma lines, cisPlatin and daunorubicin in the lung line and hydroxyurea and busulphan in the leukaemia line.

TL;DR: The association of high eZrin expression in mEIIL and its higher ability to migrate through Matrigel may at least in part indicate functional significance of ezrin in endometrial cancer metastasis.

TL;DR: It is demonstrated that CD24 is abundantly expressed on cell lines and fresh tissues of breast carcinomas and play a role in facilitating metastasis by the interaction between tumor cells and platelets or endothelial cells.

TL;DR: The effects of flavonoids on antioxidant protein expression are structure- and gene-specific, and their ability to modulate antioxidantprotein expression should also be taken into consideration when evaluating antioxidant capacity of Flavonoids.

TL;DR: Initial positive findings are stimulating the development of a more refined questionnaire instrument and its validation using food diaries, 24-h recalls, biomarkers of internal dose and direct food measurements, which should help clarify the role of doneness, cooking practices and pyrolysis products in the etiology of human cancer.

TL;DR: Findings indicate that limonene inhibits the development of gastric cancers through increased apoptosis and decreased DNA synthesis of Gastric cancers, but not through ras oncoprotein plasma membrane association.

TL;DR: The data presented herein suggest that PKC is a potential upstream target for MSC that may trigger one or all of the downstream effects; i.e. the decrease of cdk2 kinase activity, decreased DNA synthesis, elevation of gadd gene expression and finally apoptosis.

TL;DR: The results indicate that methylation of the p16INK4A gene is present in a proportion of primary gynecologic malignancies and this alteration may be associated with poor outcome in cervical and endometrial carcinomas.

TL;DR: It is suggested that antioxidants modulate ADM-induced oxidative stress, and they are discussed in terms of a possible therapeutic strategy in the prevention of cardiotoxicity resulting from ADM administration.

TL;DR: The data suggest that rodent models do not accurately represent the human response to heterocyclic amine exposure, and metabolite profiles differ substantially between humans and rodents for both MeIQx and PhIP.

TL;DR: The findings are interpreted to mean that p33 ING1 may function as a tumor suppressor in gastric carcinogenesis, even though the gene is preserved in the majority of gastrointestinal carcinomas.

TL;DR: Comparing the effects of an alternating light:dark cycle, dim light, and constant light on growth and fatty acid metabolism in rat hepatoma 7288CTC shows that dim light suppressed melatonin release by the pineal gland, increased tumor linoleic acid uptake and 13-HODE production, and promoted tumor growth as effectively as did constant light.

TL;DR: It is demonstrated that this method, which was originally established for evaluating necrosis, could be applied to measure apoptotic cell death and is useful for testing the efficacy of anti-cancer agents and for investigating the molecular mechanisms of apoptosis in the cultured cells.

TL;DR: The results suggest that KML-C is a novel lectin related to the cytotoxicity of Korean mistletoe, and that its cytotoxic activity against tumor cells is due to apoptosis mediated by Ca2+/Mg2+ -dependent endonucleases.