L
Lina Jia
Researcher at University of Minnesota
Publications - 4
Citations - 472
Lina Jia is an academic researcher from University of Minnesota. The author has contributed to research in topics: Genetically modified mouse & Chemistry. The author has an hindex of 3, co-authored 4 publications receiving 402 citations.
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Journal ArticleDOI
Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice
Wenqiang Ma,Shihua Li,Shuoqian Ma,Lina Jia,Fuchun Zhang,Yong Zhang,Jingyuan Zhang,Gary Wong,Shanshan Zhang,Xuancheng Lu,Mei Liu,Jinghua Yan,Wei Li,Chuan Qin,Daishu Han,Cheng-Feng Qin,Na Wang,Xiangdong Li,George F. Gao +18 more
TL;DR: It is demonstrated that ZIKV can induce inflammation in the testis and epididymidis, but not in the prostate or seminal vesicle, and can lead to damaged testes after 60 days post-infection in mice, and suggests that ZikV infection, under certain circumstances, can eventually lead to male infertility.
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MicroRNA-27a-3p affects estradiol and androgen imbalance by targeting Creb1 in the granulosa cells in mouse polycytic ovary syndrome model
Mingming Wang,Mei Liu,Jing Sun,Lina Jia,Shuoqian Ma,Jun Gao,Yunyun Xu,Hongwen Zhang,Suk Ying Tsang,Xiangdong Li +9 more
TL;DR: It is found that overexpression of miR-27a-3p in PCOS GCs may play an important role in ovarian follicular development and provide new insights into GC dysfunction inPCOS.
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Serum amyloid A exhibits pH dependent antibacterial action and contributes to host defense against Staphylococcus aureus cutaneous infection
Han Zheng,Haifeng Li,Jingyuan Zhang,Hanlu Fan,Lina Jia,Wenqiang Ma,Shuoqian Ma,Shenghong Wang,Hua You,Zhinan Yin,Xiangdong Li,Xiangdong Li +11 more
TL;DR: It is shown that SAA expression significantly increased in abscesses of Staphylococcus aureus cutaneous infected mice, which exert direct antibacterial effects by binding to the bacterial cell surface and disrupting the cell membrane in acidic conditions.
Journal ArticleDOI
Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance.
Yongli Qin,Lina Jia,Huijiao Liu,Wenqiang Ma,Ren Xinmin,Haifeng Li,Yuanwu Liu,Haiwen Li,Shuoqian Ma,Mei Liu,Pingping Li,Jinghua Yan,Jiyan Zhang,Yang-Dong Guo,Hua You,Yan Guo,Nafis A. Rahman,Nafis A. Rahman,Slawomir Wolczynski,Adam Kretowski,Dangsheng Li,Xiru Li,Fazheng Ren,Xiangdong Li,Xiangdong Li +24 more
TL;DR: In this article, an unexpected location and function of NOC4L, which was preferentially expressed in human and mouse macrophages, was reported, which can interact with TLR4 to inhibit its endocytosis and block the TRIF pathway, thereafter ameliorated LSI and IR in mice.