S
Shihua Li
Researcher at Chinese Academy of Sciences
Publications - 54
Citations - 3198
Shihua Li is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virus & Flavivirus. The author has an hindex of 20, co-authored 46 publications receiving 2339 citations. Previous affiliations of Shihua Li include Novartis Institute for Tropical Diseases & Academy of Military Medical Sciences.
Papers
More filters
Journal ArticleDOI
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2.
Yan Wu,Yan Wu,Feiran Wang,Feiran Wang,Chenguang Shen,Weiyu Peng,Weiyu Peng,Delin Li,Cheng Zhao,Zhaohui Li,Shihua Li,Yuhai Bi,Yang Yang,Yuhuan Gong,Haixia Xiao,Zheng Fan,Shuguang Tan,Guizhen Wu,Wenjie Tan,Xuancheng Lu,Changfa Fan,Qihui Wang,Yingxia Liu,Chen Zhang,Jianxun Qi,George F. Gao,Feng Gao,Lei Liu +27 more
TL;DR: In isolation of four human-origin monoclonal antibodies from a convalescent patient, all of which display neutralization abilities, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs.
Journal ArticleDOI
Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice
Wenqiang Ma,Shihua Li,Shuoqian Ma,Lina Jia,Fuchun Zhang,Yong Zhang,Jingyuan Zhang,Gary Wong,Shanshan Zhang,Xuancheng Lu,Mei Liu,Jinghua Yan,Wei Li,Chuan Qin,Daishu Han,Cheng-Feng Qin,Na Wang,Xiangdong Li,George F. Gao +18 more
TL;DR: It is demonstrated that ZIKV can induce inflammation in the testis and epididymidis, but not in the prostate or seminal vesicle, and can lead to damaged testes after 60 days post-infection in mice, and suggests that ZikV infection, under certain circumstances, can eventually lead to male infertility.
Journal ArticleDOI
A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS.
Lianpan Dai,Lianpan Dai,Tianyi Zheng,Kun Xu,Yuxuan Han,Lili Xu,Enqi Huang,Yaling An,Cheng Yingjie,Shihua Li,Liu Mei,Mi Yang,Yan Li,Huijun Cheng,Yuan Yuan,Wei Zhang,Changwen Ke,Gary Wong,Jianxun Qi,Chuan Qin,Jinghua Yan,George F. Gao +21 more
TL;DR: A dimeric form of MERS-CoV RBD is described that overcomes limited immunogenicity and significantly increased neutralizing antibody (NAb) titers compared to conventional monomeric form and protected mice against MSPV infection.
Journal ArticleDOI
Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Qihui Wang,Huabing Yang,Huabing Yang,Xiaoqing Liu,Lianpan Dai,Tong Ma,Tong Ma,Jianxun Qi,Gary Wong,Ruchao Peng,Sheng Liu,Sheng Liu,Junfu Li,Shihua Li,Jian Song,Jianying Liu,Jianhua He,Hui Yuan,Ying Xiong,Yong Liao,Jianhua Li,Jianping Yang,Zhou Tong,Bryan D. Griffin,Bryan D. Griffin,Yuhai Bi,Mifang Liang,Xiao-Ning Xu,Chuan Qin,Gong Cheng,Xinzheng Zhang,Peiyi Wang,Xiangguo Qiu,Xiangguo Qiu,Gary P. Kobinger,Yi Shi,Jinghua Yan,George F. Gao +37 more
TL;DR: The isolation of 13 specific human monoclonal antibodies from a patient infected with Zika virus suggest the potential of antibody-based therapeutics and provide a structure-based rationale for the design of future ZIKV-specific vaccines.
Journal ArticleDOI
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability
Xiangxi Wang,Shihua Li,Ling Zhu,Qing-Gong Nian,Shuai Yuan,Qiang Gao,Qiang Gao,Zhongyu Hu,Qing Ye,Xiaofeng Li,Dong-Yang Xie,Neil Shaw,Junzhi Wang,Thomas S. Walter,Juha T. Huiskonen,Elizabeth E. Fry,Cheng-Feng Qin,David I. Stuart,Zihe Rao,Zihe Rao +19 more
TL;DR: Cryo-electron microscopy structure of mature Japanese encephalitis virus is reported at near-atomic resolution and structural elements that modulate stability and virulence are identified, opening up new avenues for therapeutic interventions against neurotropic flaviviruses.