L
Linlin M. Chen
Researcher at Broad Institute
Publications - 12
Citations - 1735
Linlin M. Chen is an academic researcher from Broad Institute. The author has contributed to research in topics: Gene expression & RNA. The author has an hindex of 5, co-authored 9 publications receiving 874 citations. Previous affiliations of Linlin M. Chen include Wellesley College & California Institute of Technology.
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Journal ArticleDOI
Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution
Samuel G. Rodriques,Samuel G. Rodriques,Robert R. Stickels,Robert R. Stickels,Aleksandrina Goeva,Carly A. Martin,Evan Murray,Charles R. Vanderburg,Joshua D. Welch,Linlin M. Chen,Fei Chen,Evan Z. Macosko,Evan Z. Macosko +12 more
TL;DR: Slide-seq provides a scalable method for obtaining spatially resolved gene expression data at resolutions comparable to the sizes of individual cells, and defines the temporal evolution of cell type–specific responses in a mouse model of traumatic brain injury.
Journal ArticleDOI
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses.
Abhik Banerjee,Abhik Banerjee,Mario Blanco,Emily A. Bruce,Drew D. Honson,Linlin M. Chen,Amy Y. M. Chow,Prashant Bhat,Prashant Bhat,Noah Ollikainen,Sofia A. Quinodoz,Colin Loney,Jasmine Thai,Zachary D. Miller,Aaron E. Lin,Madaline M. Schmidt,Douglas G. Stewart,Daniel M. Goldfarb,Giuditta De Lorenzo,Suzannah J. Rihn,Rebecca M. Voorhees,Jason Botten,Devdoot Majumdar,Mitchell Guttman +23 more
TL;DR: The results uncover a multipronged strategy utilized by SARS-CoV-2 to antagonize essential cellular processes to suppress host defenses.
Journal ArticleDOI
Expansion microscopy of zebrafish for neuroscience and developmental biology studies
Limor Freifeld,Iris Odstrcil,Dominique Förster,Alyson N. Ramirez,James A. Gagnon,Owen Randlett,Emma K. Costa,Shoh Asano,Orhan T. Celiker,Ruixuan Gao,Daniel A. Martin-Alarcon,Paul Reginato,Paul Reginato,Cortni Dick,Linlin M. Chen,Linlin M. Chen,David Schoppik,Florian Engert,Herwig Baier,Edward S. Boyden +19 more
TL;DR: Expansion microscopy of the larval and embryonic zebrafish may enable systematic studies of how molecular components are configured in multiple contexts of interest to neuroscience and developmental biology.
Journal ArticleDOI
RNA timestamps identify the age of single molecules in RNA sequencing.
Samuel G. Rodriques,Samuel G. Rodriques,Linlin M. Chen,Sophia Liu,Sophia Liu,Ellen D. Zhong,Joseph R. Scherrer,Edward S. Boyden,Fei Chen,Fei Chen +9 more
TL;DR: RNA timestamps, a method for inferring the age of individual RNAs in RNA-seq data by exploiting RNA editing, is presented and it is demonstrated that the system can infer the presence and timing of multiple past transcriptional events.
Journal ArticleDOI
HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes
Jamie L. Marshall,Benjamin R. Doughty,Vidya Subramanian,Philine Guckelberger,Philine Guckelberger,Qingbo Wang,Qingbo Wang,Linlin M. Chen,Samuel G. Rodriques,Samuel G. Rodriques,K. Zhang,Charles P. Fulco,Joseph Nasser,Elizabeth J. Grinkevich,Teia Noel,Sarah Mangiameli,Drew T. Bergman,Anna Greka,Anna Greka,Eric S. Lander,Eric S. Lander,Eric S. Lander,Fei Chen,Jesse M. Engreitz,Jesse M. Engreitz +24 more
TL;DR: HyPR-seq as mentioned in this paper is a method for single-cell quantification of RNAs that employs hybridization of DNA probes to RNA and amplifies the probes with PCR to quantify the expression of chosen genes.