L
Linsey Stiles
Researcher at University of California, Los Angeles
Publications - 52
Citations - 4808
Linsey Stiles is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Mitochondrion & Medicine. The author has an hindex of 13, co-authored 36 publications receiving 3852 citations. Previous affiliations of Linsey Stiles include Tufts University & Boston University.
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Journal ArticleDOI
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig,Alvaro A. Elorza,Anthony J.A. Molina,Anthony J.A. Molina,Hibo Mohamed,Jakob D. Wikstrom,Gil Walzer,Linsey Stiles,Sarah E. Haigh,Steve Katz,Guy Las,Joseph Alroy,Min Wu,Bénédicte F. Py,Junying Yuan,Jude T. Deeney,Barbara E. Corkey,Orian S. Shirihai +17 more
TL;DR: Pulse chase and arrest of autophagy at the pre‐proteolysis stage reveal that fission followed by selective fusion segregates dysfunctional mitochondria and permits their removal by autophagic.
Journal ArticleDOI
Leptin Regulation of the Mesoaccumbens Dopamine Pathway
Stephanie Fulton,Pavlos Pissios,Ramon Pinol Manchon,Linsey Stiles,Lauren E. Frank,Emmanuel N. Pothos,Eleftheria Maratos-Flier,Jeffrey S. Flier +7 more
TL;DR: It is shown that ob/ob mice had diminished locomotor response to amphetamine and lacked locomotor sensitization to repeated amphetamine injections, both defects reversed by leptin infusion, and indicates that the mesoaccumbens DA pathway, critical to integrating motivated behavior, responds to this adipose-derived signal.
Journal ArticleDOI
Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis
Anthony J.A. Molina,Jakob D. Wikstrom,Jakob D. Wikstrom,Linsey Stiles,Linsey Stiles,Guy Las,Hibo Mohamed,Alvaro A. Elorza,Gil Walzer,Gilad Twig,Steve Katz,Barbara E. Corkey,Orian S. Shirihai +12 more
TL;DR: Data suggest that alterations in mitochondrial fusion and fission play a critical role in nutrient-induced β-cell apoptosis and may be involved in the pathophysiology of type 2 diabetes.
Journal ArticleDOI
Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis
Ajit S. Divakaruni,Wei Yuan Hsieh,Lucía Minarrieta,Tin Duong,Kristen K.O. Kim,Brandon R. Desousa,Alexsander Y. Andreyev,Caitlyn E. Bowman,Kacey Caradonna,Brian P. Dranka,David A. Ferrick,Marc Liesa,Linsey Stiles,George W. Rogers,Daniel Braas,Theodore P. Ciaraldi,Theodore P. Ciaraldi,Michael J. Wolfgang,Tim Sparwasser,Luciana Berod,Steven J. Bensinger,Anne N. Murphy +21 more
TL;DR: It is demonstrated that LCFA oxidation is largely dispensable for IL-4-driven polarization and an unappreciated role for CoA metabolism in macrophage polarization is revealed.
Journal ArticleDOI
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
Milica Momcilovic,Anthony E. Jones,Sean T. Bailey,Christopher M. Waldmann,Rui Li,Jason T. Lee,Gihad Abdelhady,Adrian M. Gomez,Travis Holloway,Ernst W. Schmid,David Stout,Michael C. Fishbein,Linsey Stiles,Deepa V. Dabir,Steven M. Dubinett,Heather R. Christofk,Orian S. Shirihai,Carla M. Koehler,Saman Sadeghi,David B. Shackelford +19 more
TL;DR: A positron emission tomography imaging tracer is developed to image mitochondrial function in vivo, and application of this tracer to a mouse model of lung cancer identifies distinct functional mitochondrial heterogeneity within subtypes of lung tumours.