L
Lixin Dai
Researcher at Johns Hopkins University School of Medicine
Publications - 19
Citations - 2536
Lixin Dai is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Group I catalytic intron & RNA splicing. The author has an hindex of 16, co-authored 19 publications receiving 2203 citations. Previous affiliations of Lixin Dai include University of Calgary & Johns Hopkins University.
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Journal ArticleDOI
Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
Leonora Balaj,Ryan T. Lessard,Lixin Dai,Yoon Jae Cho,Scott L. Pomeroy,Xandra O. Breakefield,Johan Skog +6 more
TL;DR: Tumour microvesicles contain a repertoire of genetic information available for horizontal gene transfer and potential use as blood biomarkers for cancer, including elevated levels of specific coding and non-coding RNA and DNA, mutated and amplified oncogene sequences and transposable elements.
Journal ArticleDOI
Long interspersed element-1 protein expression is a hallmark of many human cancers
Nemanja Rodić,Reema Sharma,Rajni Sharma,John G. Zampella,Lixin Dai,Martin S. Taylor,Ralph H. Hruban,Christine A. Iacobuzio-Donahue,Anirban Maitra,Michael Torbenson,Michael Goggins,Ie Ming Shih,Amy S. Duffield,Elizabeth A. Montgomery,Edward Gabrielson,George J. Netto,Tamara L. Lotan,Angelo M. De Marzo,William H. Westra,Zev A. Binder,Brent A. Orr,Gary L. Gallia,Charles G. Eberhart,Jef D. Boeke,Chris R. Harris,Kathleen H. Burns +25 more
TL;DR: Widespread long interspersed element-1 (LINE-1) repeat expression in human cancers is reported, showing that nearly half of all human cancers are immunoreactive for a LINE-1-encoded protein.
Journal ArticleDOI
Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition.
Martin S. Taylor,John LaCava,Paolo Mita,Kelly R. Molloy,Cheng Ran Lisa Huang,Donghui Li,Emily M. Adney,Hua Jiang,Kathleen H. Burns,Brian T. Chait,Michael P. Rout,Jef D. Boeke,Lixin Dai +12 more
TL;DR: A system to express and purify highly active L1 RNP complexes from human suspension cell culture and characterize the copurified proteome is described, identifying 37 high-confidence candidate interactors and suggesting existence of at least three types of compositionally and functionally distinct L1 RNPs.
Journal ArticleDOI
Tropism switching in Bordetella bacteriophage defines a family of diversity-generating retroelements
Sergei Doulatov,Asher Hodes,Lixin Dai,Neeraj Mandhana,Minghsun Liu,Rajendar Deora,Robert W. Simons,Steven Zimmerly,Jeff F. Miller +8 more
TL;DR: It is proposed that a TR reverse transcript is mutagenized, integrated into VR as a single non-coding strand, and then partially converted to the parental VR sequence, which allows the diversity-generating system to minimize variability to the subset of bases under selection.
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Compilation and analysis of group II intron insertions in bacterial genomes: evidence for retroelement behavior
Lixin Dai,Steven Zimmerly +1 more
TL;DR: It is suggested that group II introns in bacteria behave primarily as retroelements rather than as introns, and that the strategy for group II introns survival in bacteria is fundamentally different from intron survival in organelles.