L
Liya Gu
Researcher at University of Texas Southwestern Medical Center
Publications - 67
Citations - 3720
Liya Gu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: DNA mismatch repair & DNA repair. The author has an hindex of 32, co-authored 65 publications receiving 3314 citations. Previous affiliations of Liya Gu include University of Kentucky & University of Southern California.
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Journal ArticleDOI
The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα
TL;DR: It is shown that an epigenetic histone mark, H3K36me3, is required in vivo to recruit the mismatch recognition protein hMutSα onto chromatin through direct interactions with the hMSH6 PWWP domain.
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Reconstitution of 5'-directed human mismatch repair in a purified system.
Yanbin Zhang,Fenghua Yuan,Steven R. Presnell,Keli Tian,Yin Gao,Yin Gao,Alan E. Tomkinson,Liya Gu,Guo Min Li +8 more
TL;DR: Reconstitution of 5'-nick-directed mismatch repair using purified human proteins is reported, suggesting a model for human mismatch repair involving coordinated initiation and termination of mismatch-provoked excision.
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ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
TL;DR: It is shown that human MSH2, MLH1, PMS2 and proliferating cell nuclear antigen (PCNA) can be co-immunoprecipitated, suggesting formation of a repair initiation complex among these proteins, and that PCNA is required in human mismatch repair not only at the step of repair initiation, but also at theStep of repair DNA re-synthesis.
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Mismatch Repair Processing of Carcinogen-DNA Adducts Triggers Apoptosis
TL;DR: These studies further elucidate the mechanism by which mismatch repair deficiency predisposes to cancer, i.e., the deficiency not only causes a failure to repair mismatches generated during DNA metabolism but also fails to direct damaged and mutation-prone cells to commit suicide.
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Evidence for involvement of HMGB1 protein in human DNA mismatch repair.
TL;DR: In this article, a 30-kDa protein was purified to homogeneity by virtue of its ability to complement a depleted HeLa extract in repair of mismatched heteroduplexes.