The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα
TLDR
It is shown that an epigenetic histone mark, H3K36me3, is required in vivo to recruit the mismatch recognition protein hMutSα onto chromatin through direct interactions with the hMSH6 PWWP domain.About:
This article is published in Cell.The article was published on 2013-04-25 and is currently open access. It has received 504 citations till now. The article focuses on the topics: DNA mismatch repair & Histone code.read more
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Mechanisms of DNA damage, repair, and mutagenesis.
TL;DR: This introductory review will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells that lays the foundation for subsequent articles in this issue.
Journal ArticleDOI
Writing, erasing and reading histone lysine methylations
TL;DR: A more detailed understanding of histone lysine methylation is necessary for elucidating complex biological processes and, ultimately, for developing and improving disease treatments.
Journal ArticleDOI
Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge
Dominik Sturm,Sebastian Bender,David T.W. Jones,Peter Lichter,Jacques Grill,Oren J. Becher,Cynthia Hawkins,Jacek Majewski,Chris Jones,Joseph F. Costello,Antonio Iavarone,Kenneth Aldape,Cameron Brennan,Nada Jabado,Stefan M. Pfister +14 more
TL;DR: The hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease are summarized, and the complex interplay between the glioblastoma genome and epigenome is examined.
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SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability
Sophia X. Pfister,Sara Ahrabi,Lykourgos-Panagiotis Zalmas,Sovan Sarkar,François Aymard,François Aymard,Csanád Z. Bachrati,Thomas Helleday,Gaëlle Legube,Gaëlle Legube,Nicholas B. La Thangue,Andrew C.G. Porter,Timothy C. Humphrey +12 more
TL;DR: A role for H3K36 trimethylation in homologous recombination (HR) repair in human cells is defined and it is proposed that error-free HR repair within H3k36me3-decorated transcriptionally active genomic regions promotes cell homeostasis.
Journal ArticleDOI
ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade
Jianfeng Shen,Zhenlin Ju,Wei Zhao,Lulu Wang,Yang Peng,Zhongqi Ge,Zachary D. Nagel,Jun Zou,Chen Wang,Prabodh Kapoor,Xiangyi Ma,Ding Ma,Jiyong Liang,Shumei Song,Jinsong Liu,Leona D. Samson,Jaffer A. Ajani,Guo Min Li,Han Liang,Xuetong Shen,Gordon B. Mills,Guang Peng +21 more
TL;DR: Results suggest ARID1A deficiency contributes to impaired MMR and mutator phenotype in cancer, and may cooperate with immune checkpoint blockade therapy, complementing MSI-based prognosis.
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Mismatch repair in replication fidelity, genetic recombination, and cancer biology.
Paul Modrich,Robert S. Lahue +1 more
TL;DR: Homologs of bacterial MutS and MutL, which play key roles in mismatch recognition and initiation of repair, have been identified in yeast and mammalian cells and results in a large increase in spontaneous mutability.
Journal Article
Methylation of the hMLH1 Promoter Correlates with Lack of Expression of hMLH1 in Sporadic Colon Tumors and Mismatch Repair-defective Human Tumor Cell Lines
Michael F. Kane,Massimo Loda,Gretchen M. Gaida,Lipman J,Rajesh Mishra,Harvey Goldman,J. M. Jessup,Richard D. Kolodner +7 more
TL;DR: Analysis of sporadic colorectal tumors for the expression of hMLH1 by immunohistochemistry indicates that DNA methylation is likely to be a common mode of mismatch repair gene inactivation in sporadic tumors.
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