L
Lizbeth M. Hoos
Researcher at Schering-Plough
Publications - 26
Citations - 4494
Lizbeth M. Hoos is an academic researcher from Schering-Plough. The author has contributed to research in topics: Ezetimibe & Cholesterol absorption inhibitor. The author has an hindex of 20, co-authored 26 publications receiving 4265 citations.
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Journal ArticleDOI
Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.
Scott W. Altmann,Harry R. Davis,Li-ji Zhu,Xiaorui Yao,Lizbeth M. Hoos,Glen Tetzloff,Sai Prasad N. Iyer,Maureen Maguire,Andrei Golovko,Ming Zeng,Luquan Wang,Nicholas J. Murgolo,Michael P. Graziano +12 more
TL;DR: It is shown that Niemann-Pick C1Like 1(NPC1L1) protein plays a critical role in the absorption of intestinal cholesterol, and resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption.
Journal ArticleDOI
Niemann-Pick C1 Like 1 (NPC1L1) Is the Intestinal Phytosterol and Cholesterol Transporter and a Key Modulator of Whole-body Cholesterol Homeostasis
Harry R. Davis,Li-ji Zhu,Lizbeth M. Hoos,Glen Tetzloff,Maureen Maguire,Jianjun Liu,Xiaorui Yao,Sai Prasad N Iyer,My-Hanh Lam,Erik G. Lund,Patricia A. Detmers,Michael P. Graziano,Scott W. Altmann +12 more
TL;DR: NPC1L1 is required for intestinal uptake of both cholesterol and phytosterols and plays a major role in cholesterol homeostasis and may be a useful drug target for the treatment of hypercholesterolemia and sitosterolemia.
Journal ArticleDOI
Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663
Margaret van Heek,Constance Farley,Douglas S Compton,Lizbeth M. Hoos,Kevin B. Alton,Edmund J. Sybertz,Harry R. Davis +6 more
TL;DR: It is demonstrated that the phenolic glucuronide (SCH60663) of SCH58 235, was more potent at inhibiting cholesterol absorption in rats than SCH58235, when administered by the intraduodenal route.
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Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation.
Galya Vassileva,Andrei Golovko,Lisa Markowitz,Susan J. Abbondanzo,Ming Zeng,Shijun Yang,Lizbeth M. Hoos,Glen Tetzloff,Diane Levitan,Nicholas J. Murgolo,Kevin R. Keane,Harry R. Davis,Joseph A. Hedrick,Eric L. Gustafson +13 more
TL;DR: The results suggest that Gpbar1 plays a critical role in the formation of gallstones, possibly via a regulatory mechanism involving the cholesterol 7alpha-hydroxylase pathway.
Journal ArticleDOI
Ezetimibe, a Potent Cholesterol Absorption Inhibitor, Inhibits the Development of Atherosclerosis in ApoE Knockout Mice
TL;DR: Ezetimibe inhibits cholesterol absorption, reduces plasma cholesterol, increases high density lipoprotein levels, and inhibits the progression of atherosclerosis under western, low-fat, and cholesterol-free dietary conditions in apoE−/− mice.