Xiaorui Yao

TL;DR: It is shown that Niemann-Pick C1Like 1(NPC1L1) protein plays a critical role in the absorption of intestinal cholesterol, and resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption.

TL;DR: NPC1L1 is required for intestinal uptake of both cholesterol and phytosterols and plays a major role in cholesterol homeostasis and may be a useful drug target for the treatment of hypercholesterolemia and sitosterolemia.

TL;DR: The binding of ezetimibe to cells expressing SR-B1 and the functional blockade of SR-b1-mediated cholesterol absorption in vitro suggest that SR- B1 plays a role in intestinal cholesterol metabolism and the inhibitory activity of eZetimibes.

TL;DR: A molecular model of the human melanin-concentrating hormone (MCH) peptide was constructed and docked into a helical, bacteriorhodopsin-basedmodel of the recently identified human MCH receptor, and it is proposed that both Asp(123)(3.32) in the MCH receptors and Arg(11) inthe MCH peptide are required for the formation of the M CH peptide/receptor complex.

TL;DR: Biochemical data indicate that NPC1L1 exists as a predominantly cell surface membrane expressed protein, consistent with its proposed role as the putative intestinal sterol transporter.