L
Long Mao
Publications - 8
Citations - 499
Long Mao is an academic researcher. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 4, co-authored 4 publications receiving 445 citations.
Papers
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Journal ArticleDOI
Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease
Maria Z. Kounnas,Anne M. Danks,Soan Cheng,Curtis M. Tyree,Elizabeth J. Ackerman,Xulun Zhang,Kwangwook Ahn,Phuong T. Nguyen,Dan Comer,Long Mao,Chengzhi Yu,David P. M. Pleynet,Paul J. Digregorio,Gonul Velicelebi,Kenneth A. Stauderman,William T. Comer,William C. Mobley,Yue-Ming Li,Sangram S. Sisodia,Rudolph E. Tanzi,Steven L. Wagner +20 more
TL;DR: Over 1200 novel gamma-secretase modulator compounds were synthesized that reduced Abeta(42) levels without inhibiting epsilon-site cleavage of APP and Notch, the generation of the APP and notch intracellular domains, respectively.
Patent
Compounds and uses thereof in modulating amyloid beta
TL;DR: In this paper, novel compounds, compositions, and kits are provided for modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ level are also provided.
Journal ArticleDOI
Extraction, Structure and Immunoregulatory Activity of Low Molecular Weight Polysaccharide from Dendrobium officinale
TL;DR: In this paper , the extraction, physicochemical properties, and immune regulation activity of an edible D. officinale polysaccharide (DOPs) isolated from the supernatant after 75% ethanol precipitation were systematically investigated.
Patent
Methods of modulating amyloid beta and compounds useful therefor
TL;DR: In this paper, novel compounds have been discovered that are useful for a variety of therapeutic applications, e.g., for modulating amyloid-beta levels, which are applicable for treating diseases associated with aberrant levels of Aβ and/or any condition in which modulation of A β levels provides a therapeutic effect.
Journal ArticleDOI
Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
TL;DR: Zhang et al. as discussed by the authors investigated the potential inhibitory mechanism of selenium-modified chitosan (SMC) on HepG2 cells through MTT assays, morphological observation, annexin V-FITC/PI double staining, mitochondrial membrane potential determination, cell-cycle detection, Western blotting, and two-dimensional gel electrophoresis.