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William T. Comer
Publications - 7
Citations - 287
William T. Comer is an academic researcher. The author has contributed to research in topics: Gamma secretase & Cognitive decline. The author has an hindex of 3, co-authored 7 publications receiving 267 citations.
Papers
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Journal ArticleDOI
Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease
Maria Z. Kounnas,Anne M. Danks,Soan Cheng,Curtis M. Tyree,Elizabeth J. Ackerman,Xulun Zhang,Kwangwook Ahn,Phuong T. Nguyen,Dan Comer,Long Mao,Chengzhi Yu,David P. M. Pleynet,Paul J. Digregorio,Gonul Velicelebi,Kenneth A. Stauderman,William T. Comer,William C. Mobley,Yue-Ming Li,Sangram S. Sisodia,Rudolph E. Tanzi,Steven L. Wagner +20 more
TL;DR: Over 1200 novel gamma-secretase modulator compounds were synthesized that reduced Abeta(42) levels without inhibiting epsilon-site cleavage of APP and Notch, the generation of the APP and notch intracellular domains, respectively.
Journal ArticleDOI
NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.
TL;DR: Alzheimer's disease (AD) is defined by the progressive accumulation of amyloid plaques and neurofibrillary tangles in the brain which precedes cognitive decline by years.
Patent
Recombinant amyloid precursor protein inhibitor domain and treatment of various disease states
Steven L. Wagner,Robert Steven Siegel,Gregory Patrick Thill,Michael M. Harpold,William T. Comer +4 more
TL;DR: In this article, the Kuniz type protease inhibitor (KPI) peptide is used to regulate protease activity associated with amyloidosis. But, the KPI peptide can also be used to treat coagulation disorders by regulating proteases in the co-agulation pathway.
Journal ArticleDOI
NGP 555, a γ-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses
TL;DR: This booklet explains how to identify and treat Alzheimer's disease using a probabilistic approach, and some examples show the different approaches used to diagnose and treat the disease.
Patent
Formulations containing gamma secretase modulators
TL;DR: In this article, the authors provided formulations of gamma secretase modulators (GSMs) which are suitable for oral delivery and have improved transport properties relative to prior art formulations thereof.