L
Louise E. Reynolds
Researcher at Queen Mary University of London
Publications - 49
Citations - 3551
Louise E. Reynolds is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Angiogenesis & Neovascularization. The author has an hindex of 25, co-authored 47 publications receiving 3115 citations. Previous affiliations of Louise E. Reynolds include St Thomas' Hospital.
Papers
More filters
Journal ArticleDOI
Enhanced Pathological Angiogenesis in Mice Lacking beta3 Integrin or beta3 and beta5 Integrins
Louise E. Reynolds,Lorenza Wyder,Julie C. Lively,Daniela Taverna,Stephen D. Robinson,Xiaozhu Huang,Dean Sheppard,Richard O. Hynes,Kairbaan Hodivala-Dilke +8 more
TL;DR: It is reported that mice lacking β3Integrins or both β3 and β5 integrins not only support tumorigenesis, but have enhanced tumor growth as well and the tumors in these integrin-deficient mice display enhanced angiogenesis, strongly suggesting that neither β3 nor β5integrins are essential for neovascularization.
Journal ArticleDOI
Integrins: The Keys to Unlocking Angiogenesis
TL;DR: The contribution of endothelial and mural cell integrins to angiogenesis is reviewed and their potential as antiangiogenesis targets are highlighted.
Journal ArticleDOI
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression
Gordon W. McLean,Noboru H. Komiyama,Bryan Serrels,Hidefumi Asano,Louise E. Reynolds,Francesco J. Conti,Kairbaan Hodivala-Dilke,Daniel Metzger,Pierre Chambon,Seth G. N. Grant,Margaret C. Frame +10 more
TL;DR: This work provides the first experimental proof implicating FAK in tumorigenesis, and this is associated with enhanced apoptosis, and it is found no effect on wound re-epithelialization in vivo.
Journal ArticleDOI
The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/β-Catenin Signaling
Graeme M. Birdsey,Aarti V. Shah,Neil Dufton,Louise E. Reynolds,Lourdes Osuna Almagro,Youwen Yang,Irene M. Aspalter,Samia Taufiq Khan,Justin C. Mason,Elisabetta Dejana,Berthold Göttgens,Kairbaan Hodivala-Dilke,Holger Gerhardt,Ralf H. Adams,Anna M. Randi +14 more
TL;DR: It is demonstrated that ERG is an essential regulator of angiogenesis and vascular stability through Wnt signaling through signals mediated by VE-cadherin and the Wnt receptor Frizzled-4.
Journal ArticleDOI
Interleukin-6 stimulates defective angiogenesis
Ganga Gopinathan,Carla Milagre,Oliver M. T. Pearce,Louise E. Reynolds,Kairbaan Hodivala-Dilke,David A. Leinster,Haihong Zhong,Robert E. Hollingsworth,Richard G. Thompson,James R. Whiteford,Frances R. Balkwill +10 more
TL;DR: It is shown that IL6 can directly induce vessel sprouting in the ex vivo aortic ring model, as well as endothelial cell proliferation and migration, with similar potency to VEGF.