Louise M. Perkins

TL;DR: The massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs indicates that cancer genome sequencing of large collections of samples will yield new insights into cancer not anticipated by existing knowledge.

TL;DR: In this paper, a massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs was reported, and several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set.

TL;DR: This article performed massively parallel sequencing of paired tumor/normal samples from 203 multiple myeloma (MM) patients and identified significantly mutated genes and copy number alterations and discovered putative tumor suppressor genes by determining homozygous deletions and loss of heterozygosity.

TL;DR: A kinome-wide small interfering RNA (siRNA) lethality study in myeloma tumor lines bearing common t(4;14), t(14;16), and t(11;14) translocations is conducted to identify critically vulnerable kinases in myELoma tumor cells without regard to preconceived mechanistic notions.

TL;DR: This study represents the first comprehensive comparisons of the frequency and distribution of molecular alterations in MM tumors between AA and EA patients and shows no significant difference in the frequency of high-risk disease based on gene expression profiling.