L
Lu Bai
Researcher at Pennsylvania State University
Publications - 50
Citations - 2435
Lu Bai is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Nucleosome & Gene. The author has an hindex of 18, co-authored 41 publications receiving 2060 citations. Previous affiliations of Lu Bai include Rockefeller University & Cornell University.
Papers
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Journal ArticleDOI
High-resolution dynamic mapping of histone-DNA interactions in a nucleosome
Michael Hall,Alla Shundrovsky,Alla Shundrovsky,Lu Bai,Lu Bai,Robert M. Fulbright,John T. Lis,Michelle D. Wang,Michelle D. Wang +8 more
TL;DR: In this paper, a detailed histone-DNA interaction map was presented by mechanically unzipping single molecules of DNA, each containing a single nucleosome, revealing a distinct approximately 5-bp periodicity that was enveloped by three broad regions of strong interactions.
Journal ArticleDOI
Transcription under torsion.
TL;DR: Direct measurements of individual Escherichia coli RNAPs as they transcribed supercoiled DNA provide a quantitative framework for understanding how dynamic modification of DNA supercoiling regulates transcription.
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Single-Molecule Studies Reveal Dynamics of DNA Unwinding by the Ring-Shaped T7 Helicase
TL;DR: In insights into possible ways helicase activity is enhanced by associated proteins, an active unwinding model fully supports the data even though the helicase on its own does not unwind at its optimal rate.
Journal ArticleDOI
Gene regulation by nucleosome positioning.
Lu Bai,Alexandre V. Morozov +1 more
TL;DR: This work has shown that across all eukaryotic species, promoters and other regulatory sequences are more nucleosome-depleted, whereas transcribed regions tend to be occupied with well-positioned, high-density nucleosomal arrays.
Journal ArticleDOI
Sequence-dependent kinetic model for transcription elongation by RNA polymerase.
TL;DR: The model provides a kinetic explanation for well-known back-tracked pauses at transcript positions with unstable TECs and predicts a new type of pause caused by an energetically unfavorable transition from pre to post-translocation modes.