L
Luca Gambazzi
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 7
Citations - 947
Luca Gambazzi is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Microelectrode & Neurotrophic factors. The author has an hindex of 6, co-authored 7 publications receiving 887 citations. Previous affiliations of Luca Gambazzi include MIND Institute & University of Antwerp.
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Journal ArticleDOI
Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts
Giada Cellot,Emanuele Cilia,Emanuele Cilia,Sara Cipollone,Vladimir Rancic,Antonella Sucapane,Silvia Giordani,Silvia Giordani,Luca Gambazzi,Henry Markram,Micaela Grandolfo,Denis Scaini,Fabrizio Gelain,Loredana Casalis,Maurizio Prato,Michele Giugliano,Michele Giugliano,Laura Ballerini +17 more
TL;DR: It is shown, using single-cell electrophysiology techniques, electron microscopy analysis and theoretical modelling, that nanotubes improve the responsiveness of neurons by forming tight contacts with the cell membranes that might favour electrical shortcuts between the proximal and distal compartments of the neuron.
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Interfacing Neurons with Carbon Nanotubes: Electrical Signal Transfer and Synaptic Stimulation in Cultured Brain Circuits
Andrea Mazzatenta,Michele Giugliano,Stéphane Campidelli,Luca Gambazzi,Luca Businaro,Henry Markram,Maurizio Prato,Laura Ballerini +7 more
TL;DR: Results clearly indicate that SWNTs can directly stimulate brain circuit activity and are supported by mathematical models to describe the electrical interactions occurring in SWNT–neuron hybrid systems.
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Channelpedia: an integrative and interactive database for ion channels.
Rajnish Ranjan,Georges Khazen,Luca Gambazzi,Srikanth Ramaswamy,Sean Hill,Felix Schürmann,Henry Markram +6 more
TL;DR: “Channelpedia” is presented, which is designed to store information related to ion channels and models and is characterized by an efficient information management framework and currently contains 187 annotated ion channels with 45 Hodgkin–Huxley models.
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Multiwalled Carbon-Nanotube-Functionalized Microelectrode Arrays Fabricated by Microcontact Printing: Platform for Studying Chemical and Electrical Neuronal Signaling
Kai Fuchsberger,Alan Le Goff,Luca Gambazzi,Luca Gambazzi,Francesca M. Toma,Andrea Goldoni,Michele Giugliano,Michele Giugliano,Martin Stelzle,Maurizio Prato +9 more
TL;DR: Preliminary electrophysiological measurements show that MWCNT microelectrodes have recording properties superior to those of commercial TiN microElectrodes when detecting neuronal electrical activity under long-term cell-culture conditions.
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Diminished Activity-Dependent Brain-Derived Neurotrophic Factor Expression Underlies Cortical Neuron Microcircuit Hypoconnectivity Resulting from Exposure to Mutant Huntingtin Fragments
Luca Gambazzi,Ozgun Gokce,Tamara Seredenina,Elena Katsyuba,Heike Runne,Henry Markram,Michele Giugliano,Ruth Luthi-Carter +7 more
TL;DR: A novel HD-related deficit in BDNF gene regulation is elucidated as a plausible mechanism of cortical neuron hypoconnectivity and cortical function deficits in HD.