O
Ozgun Gokce
Researcher at Ludwig Maximilian University of Munich
Publications - 44
Citations - 4701
Ozgun Gokce is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Neurexin & Huntingtin. The author has an hindex of 22, co-authored 34 publications receiving 3050 citations. Previous affiliations of Ozgun Gokce include École Polytechnique Fédérale de Lausanne & Stanford University.
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Journal ArticleDOI
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.
Ludovico Cantuti-Castelvetri,Ludovico Cantuti-Castelvetri,Ravi Ojha,Liliana D. Pedro,Liliana D. Pedro,Minou Djannatian,Minou Djannatian,Jonas Franz,Suvi Kuivanen,Franziska van der Meer,Katri Kallio,Tuğberk Kaya,Tuğberk Kaya,Tuğberk Kaya,Maria Anastasina,Maria Anastasina,Teemu Smura,Lev Levanov,Leonora Szirovicza,Allan Tobi,Hannimari Kallio-Kokko,Pamela Österlund,Merja Joensuu,Frederic A. Meunier,Sarah J. Butcher,Sarah J. Butcher,Martin Sebastian Winkler,Brit Mollenhauer,Ari Helenius,Ozgun Gokce,Tambet Teesalu,Tambet Teesalu,Tambet Teesalu,Jussi Hepojoki,Jussi Hepojoki,Olli Vapalahti,Christine Stadelmann,Giuseppe Balistreri,Giuseppe Balistreri,Mikael Simons,Mikael Simons +40 more
TL;DR: It is found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1.
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Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors.
Patrick E. Rothwell,Marc V. Fuccillo,Stephan Maxeiner,Scott J. Hayton,Ozgun Gokce,Byung Kook Lim,Stephen C. Fowler,Robert C. Malenka,Thomas C. Südhof +8 more
TL;DR: It is suggested that different autism-associated neuroligin-3 mutations cause a common increase in acquired repetitive behaviors by impairing a specific striatal synapse and thereby provide a plausible circuit substrate for autism pathophysiology.
Journal ArticleDOI
Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq
Ozgun Gokce,Ozgun Gokce,Geoffrey Stanley,Barbara Treutlein,Norma F. Neff,J. Gray Camp,Robert C. Malenka,Patrick E. Rothwell,Marc V. Fuccillo,Thomas C. Südhof,Thomas C. Südhof,Stephen R. Quake,Stephen R. Quake +12 more
TL;DR: This work shows that microfluidic and FACS-based single-cell RNA sequencing of mouse striatum provides a well-resolved classification of striatal cell type diversity, and identifies cell type-specific transcription and splicing factors that shape cellular identities by regulating splicing and expression patterns.
Journal ArticleDOI
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
Ruth Luthi-Carter,David Taylor,Judit Pallos,Emmanuel Lambert,Allison M. Amore,Alex Parker,Hilary Moffitt,Donna L. Smith,Heike Runne,Ozgun Gokce,Alexandre Kuhn,Zhongmin Xiang,Michele M. Maxwell,Steven A. Reeves,Gillian P. Bates,Christian Neri,Leslie M. Thompson,J. Lawrence Marsh,Aleksey G. Kazantsev +18 more
TL;DR: It is demonstrated that inhibition of sirtuin 2 (SIRT2) achieves neuroprotection in cellular and invertebrate models of HD by manipulating sterol biosynthesis at the transcriptional level, demonstrating that the metabolic effects of SIRT2 inhibition are sufficient to diminish mutant huntingtin toxicity.
Journal ArticleDOI
Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing
TL;DR: The data suggest that thousands of neurexin isoforms are physiologically generated, consistent with the notion that α-neurexins represent transsynaptic protein-interaction scaffolds that mediate diverse functions and are regulated by alternative splicing at multiple independent sites.