L
Luca Gattinoni
Researcher at University of Regensburg
Publications - 130
Citations - 20804
Luca Gattinoni is an academic researcher from University of Regensburg. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 60, co-authored 130 publications receiving 17727 citations. Previous affiliations of Luca Gattinoni include National Institutes of Health & Vita-Salute San Raffaele University.
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Journal ArticleDOI
A human memory T cell subset with stem cell-like properties
Luca Gattinoni,Enrico Lugli,Yun Ji,Zoltan Pos,Chrystal M. Paulos,Máire F. Quigley,Máire F. Quigley,Jorge R. Almeida,Emma Gostick,Zhiya Yu,Carmine Carpenito,Ena Wang,Daniel C. Douek,David Price,David Price,Carl H. June,Francesco M. Marincola,Mario Roederer,Nicholas P. Restifo +18 more
TL;DR: A long-lived human memory T cell population that has an enhanced capacity for self-renewal and a multipotent ability to derive central memory, effector memory and effector T cells is described.
Journal ArticleDOI
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
Luca Gattinoni,Steven E. Finkelstein,Christopher A. Klebanoff,Christopher A. Klebanoff,Paul A. Antony,Douglas C. Palmer,Paul J. Spiess,Leroy N. Hwang,Zhiya Yu,Claudia Wrzesinski,David M. Heimann,Charles D. Surh,Steven A. Rosenberg,Nicholas P. Restifo +13 more
TL;DR: It is found that even in the genetic absence of T reg cells, a nonmyeloablative regimen substantially augmented CD8+ T cell reactivity to self-tissue and tumor, and the restricted availability of homeostatic cytokines can be a contributing factor to peripheral tolerance, as well as a limiting resource for the effectiveness of tumor-specific T cells.
Journal ArticleDOI
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
Luca Gattinoni,Christopher A. Klebanoff,Christopher A. Klebanoff,Douglas C. Palmer,Claudia Wrzesinski,Keith W. Kerstann,Zhiya Yu,Steven E. Finkelstein,Marc R. Theoret,Steven A. Rosenberg,Nicholas P. Restifo +10 more
TL;DR: The findings suggest that the current methodology for selecting T cells for transfer is inadequate and provide new criteria for the generation and the screening of optimal lymphocyte populations for adoptive immunotherapy.
Journal ArticleDOI
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells
Christopher A. Klebanoff,Luca Gattinoni,Parizad Torabi-Parizi,Keith W. Kerstann,Adela R. Cardones,Steven E. Finkelstein,Douglas C. Palmer,Paul A. Antony,Samuel T Hwang,Steven A. Rosenberg,Thomas A. Waldmann,Nicholas P. Restifo +11 more
TL;DR: T tumor-reactive CD8+ T cell populations with the phenotypic and functional attributes of T(CM) may be superior to T(EM)/effector T cells for adoptive immunotherapies using concomitant tumor-antigen vaccination.
Journal ArticleDOI
Adoptive immunotherapy for cancer: building on success.
TL;DR: How a lymphopaenic environment enables tumour-reactive T cells to destroy large burdens of metastatic tumour and how the state of differentiation of the adoptively transferred T cells can affect the outcome of treatment are described.