L
Lucia Amico
Researcher at University of Perugia
Publications - 9
Citations - 412
Lucia Amico is an academic researcher from University of Perugia. The author has contributed to research in topics: Acute leukemia & Transplantation. The author has an hindex of 4, co-authored 9 publications receiving 351 citations.
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Journal ArticleDOI
HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
Massimo F. Martelli,Mauro Di Ianni,Mauro Di Ianni,Loredana Ruggeri,Franca Falzetti,Alessandra Carotti,Adelmo Terenzi,Antonio Pierini,Maria Speranza Massei,Lucia Amico,Elena Urbani,Beatrice Del Papa,Tiziana Zei,Roberta Iacucci Ostini,Debora Cecchini,Rita Tognellini,Yair Reisner,Franco Aversa,Brunangelo Falini,Andrea Velardi +19 more
TL;DR: It is demonstrated the immunosuppressive potential of Tregs can be used to suppress GVHD without loss of the benefits of graft-versus-leukemia (GVL) activity, and humanized murine models provided insights into the mechanisms underlying separation of GVL from GV HD.
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Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1.
Vasilis Oikonomou,Silvia Moretti,Giorgia Renga,Claudia Galosi,Monica Borghi,Marilena Pariano,Matteo Puccetti,Carlo Alberto Palmerini,Lucia Amico,Alessandra Carotti,Lucia Prezioso,Angelica Spolzino,Andrea Finocchi,Paolo Rossi,Andrea Velardi,Franco Aversa,Valerio Napolioni,Luigina Romani +17 more
TL;DR: DAPK1 is a potential drugable player in regulating the inflammatory response during fungal clearance initiated by IFN-γ, in mouse models and patient samples of chronic granulomatous disease and in a cohort of hematopoietic stem cell-transplanted patients.
Journal ArticleDOI
Tregs Suppress GvHD at the Periphery and Unleash the Gvl Effect in the Bone Marrow
Loredana Ruggeri,Mauro Di Ianni,Mauro Di Ianni,Elena Urbani,Antonella Mancusi,Franca Falzetti,Alessandra Carotti,Adelmo Terenzi,Maria Speranza Massei,Lucia Amico,Tiziana Zei,Roberta Iacucci,Massimo F. Martelli,Andrea Velardi +13 more
TL;DR: Treg/Tcon adoptive immunotherapy mediates GvL effect in the absence of GvHD because Tcons that home to the bone marrow exert unopposed alloantigen recognition, while T Cons thatHome to the periphery are blocked by Tregs.
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The Total Body Irradiation Schedule Affects Acute Leukemia Relapse After Matched T Cell-Depleted Hematopoietic Stem Cell Transplantation.
Cynthia Aristei,Alessandra Carotti,E. Palazzari,Lucia Amico,Loredana Ruggeri,Elisabetta Perrucci,Lorenzo Falcinelli,Valentina Lancellotta,Isabella Palumbo,Franca Falzetti,Franco Aversa,Mara Merluzzi,Andrea Velardi,Massimo F. Martelli +13 more
TL;DR: In patients with acute leukemia, HTBI is more efficacious than STBI in eradicating minimal residual disease after HLA-matched T cell-depleted hematopoietic stem cell transplantation, thus affecting DFS.
Journal ArticleDOI
Total Marrow/Total Lymphoid Irradiation as Conditioning for Haploidentical Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia Patients
Cynthia Aristei,Valentina Lancellotta,Alessandra Carotti,C. Zucchetti,Antonio Pierini,Simonetta Saldi,Loredana Ruggeri,Lucia Amico,M. Iacco,Andrea Velardi,Massimo F. Martelli +10 more