T
Tiziana Zei
Researcher at University of Perugia
Publications - 32
Citations - 2329
Tiziana Zei is an academic researcher from University of Perugia. The author has contributed to research in topics: Leukemia & Transplantation. The author has an hindex of 13, co-authored 29 publications receiving 2174 citations.
Papers
More filters
Journal ArticleDOI
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
Mauro Di Ianni,Mauro Di Ianni,Franca Falzetti,Alessandra Carotti,Adelmo Terenzi,Flora Castellino,Elisabetta Bonifacio,Beatrice Del Papa,Tiziana Zei,Roberta Iacucci Ostini,Debora Cecchini,Teresa Aloisi,Katia Perruccio,Loredana Ruggeri,Chiara Balucani,Antonio Pierini,Paolo Sportoletti,Cynthia Aristei,Brunangelo Falini,Yair Reisner,Andrea Velardi,Franco Aversa,Massimo F. Martelli +22 more
TL;DR: It is shown for the first time in humans that adoptive transfer of Tregs prevented GVHD in the absence of any posttransplantation immunosuppression, promoted lymphoid reconstitution, improved immunity to opportunistic pathogens, and did not weaken the graft-versus-leukemia effect.
Journal ArticleDOI
Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum
Franco Aversa,Antonio Tabilio,Adelmo Terenzi,Andrea Velardi,Franca Falzetti,C Giannoni,Roberta Iacucci,Tiziana Zei,Maria Paola Martelli,C. Gambelunghe +9 more
TL;DR: Results show that a highly immunosuppressive and myeloablative conditioning followed by transplantation of a large number of stem cells depleted of T lymphocytes by soybean agglutination and E-rosetting technique has made transplation of three HLA-antigen disparate grafts possible, with only rare cases of GVHD.
Journal ArticleDOI
HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
Massimo F. Martelli,Mauro Di Ianni,Mauro Di Ianni,Loredana Ruggeri,Franca Falzetti,Alessandra Carotti,Adelmo Terenzi,Antonio Pierini,Maria Speranza Massei,Lucia Amico,Elena Urbani,Beatrice Del Papa,Tiziana Zei,Roberta Iacucci Ostini,Debora Cecchini,Rita Tognellini,Yair Reisner,Franco Aversa,Brunangelo Falini,Andrea Velardi +19 more
TL;DR: It is demonstrated the immunosuppressive potential of Tregs can be used to suppress GVHD without loss of the benefits of graft-versus-leukemia (GVL) activity, and humanized murine models provided insights into the mechanisms underlying separation of GVL from GV HD.
Journal ArticleDOI
Improved Outcome With T-Cell–Depleted Bone Marrow Transplantation for Acute Leukemia
Franco Aversa,Adelmo Terenzi,Alessandra Carotti,Rita Felicini,Roberta Jacucci,Tiziana Zei,Paolo Latini,Cynthia Aristei,Antonella Santucci,Maria Paola Martelli,Isabel Cunningham,Yair Reisner,Massimo F. Martelli +12 more
TL;DR: Adding antithymocyte globulin and thiotepa to the conditioning regimen prevents rejection of extensively T-cell-depleted bone marrow in acute leukemia patients, and even in the complete absence of GVHD, the leukemia relapse rate is not higher than in unmanipulated transplants.
Journal ArticleDOI
Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applications
M Di Ianni,B. Del Papa,Debora Cecchini,Elisabetta Bonifacio,Lorenzo Moretti,Tiziana Zei,R. Iacucci Ostini,Franca Falzetti,L. Fontana,G. Tagliapietra,C. Maldini,Massimo F. Martelli,Antonio Tabilio +12 more
TL;DR: This study shows that negative/positive Treg selection, performed using the CliniMACS device and reagents, enriches significantly CD4+CD25+FoxP3+ cells endowed with immunosuppressive capacities.