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Beatrice Del Papa
Researcher at University of Perugia
Publications - 38
Citations - 2230
Beatrice Del Papa is an academic researcher from University of Perugia. The author has contributed to research in topics: Chronic lymphocytic leukemia & T cell. The author has an hindex of 14, co-authored 36 publications receiving 1990 citations.
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Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
Mauro Di Ianni,Mauro Di Ianni,Franca Falzetti,Alessandra Carotti,Adelmo Terenzi,Flora Castellino,Elisabetta Bonifacio,Beatrice Del Papa,Tiziana Zei,Roberta Iacucci Ostini,Debora Cecchini,Teresa Aloisi,Katia Perruccio,Loredana Ruggeri,Chiara Balucani,Antonio Pierini,Paolo Sportoletti,Cynthia Aristei,Brunangelo Falini,Yair Reisner,Andrea Velardi,Franco Aversa,Massimo F. Martelli +22 more
TL;DR: It is shown for the first time in humans that adoptive transfer of Tregs prevented GVHD in the absence of any posttransplantation immunosuppression, promoted lymphoid reconstitution, improved immunity to opportunistic pathogens, and did not weaken the graft-versus-leukemia effect.
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HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
Massimo F. Martelli,Mauro Di Ianni,Mauro Di Ianni,Loredana Ruggeri,Franca Falzetti,Alessandra Carotti,Adelmo Terenzi,Antonio Pierini,Maria Speranza Massei,Lucia Amico,Elena Urbani,Beatrice Del Papa,Tiziana Zei,Roberta Iacucci Ostini,Debora Cecchini,Rita Tognellini,Yair Reisner,Franco Aversa,Brunangelo Falini,Andrea Velardi +19 more
TL;DR: It is demonstrated the immunosuppressive potential of Tregs can be used to suppress GVHD without loss of the benefits of graft-versus-leukemia (GVL) activity, and humanized murine models provided insights into the mechanisms underlying separation of GVL from GV HD.
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Mesenchymal cells recruit and regulate T regulatory cells
Mauro Di Ianni,Beatrice Del Papa,Maria De Ioanni,Lorenzo Moretti,Elisabetta Bonifacio,Debora Cecchini,Paolo Sportoletti,Franca Falzetti,Antonio Tabilio +8 more
TL;DR: It is demonstrated that MSCs recruit, regulate, and maintain T-regulatory phenotype and function over time.
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NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL.
Paolo Sportoletti,Stefano Baldoni,Laura Cavalli,Beatrice Del Papa,Elisabetta Bonifacio,Raffaella Ciurnelli,Alain Sylvin Bell,Ambra Di Tommaso,Emanuela Rosati,Barbara Crescenzi,Cristina Mecucci,Isabella Screpanti,Pierfrancesco Marconi,Massimo F. Martelli,Mauro Di Ianni,Franca Falzetti +15 more
TL;DR: A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens, and characterization and localization of the Gova/b alloantsigens to the glycosylphosphatidylinositol-anchored protein CDw109 on human platelets.
Journal ArticleDOI
Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction.
Beatrice Del Papa,Paolo Sportoletti,Debora Cecchini,Emanuela Rosati,Chiara Balucani,Stefano Baldoni,Katia Fettucciari,Pierfrancesco Marconi,Massimo F. Martelli,Franca Falzetti,Mauro Di Ianni,Mauro Di Ianni +11 more
TL;DR: It is shown that the Notch1 pathway is activated in CD4+ T cells cocultured with MSCs, and it is demonstrated that FOXP3 is a downstream target of Notch signaling in human cells.