L
Luciano Marcon
Researcher at Spanish National Research Council
Publications - 14
Citations - 1245
Luciano Marcon is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Turing & Limb development. The author has an hindex of 9, co-authored 12 publications receiving 1028 citations. Previous affiliations of Luciano Marcon include European Bioinformatics Institute & Pablo de Olavide University.
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Journal ArticleDOI
Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients
TL;DR: Evidence is revealed that a Turing network implemented by Bmp, Sox9, and Wnt drives digit specification and a realistic two-dimensional simulation of digit patterning is developed, which shows that this network, when modulated by morphogen gradients, recapitulates the expression patterns of Sox9 in the wild type and in perturbation experiments.
Journal ArticleDOI
Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism
Rushikesh Sheth,Luciano Marcon,Luciano Marcon,M. Félix Bastida,M. Félix Bastida,Marisa Junco,Laura Quintana,Laura Quintana,Randall D. Dahn,Marie Kmita,James Sharpe,James Sharpe,James Sharpe,Maria A. Ros,Maria A. Ros +14 more
TL;DR: Mouse genetics and computer modeling are used to argue for a Turing-type mechanism underlying digit patterning, in which the dose of distal Hox genes modulates the digit period or wavelength.
Journal ArticleDOI
High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals
Luciano Marcon,Xavier Diego,Xavier Diego,James Sharpe,James Sharpe,James Sharpe,Patrick Müller +6 more
TL;DR: An automated mathematical analysis is developed to derive a catalog of realistic Turing networks that reveal that in the presence of cell-autonomous factors, networks can form a pattern with equally diffusing signals and even for any combination of diffusion coefficients.
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Turing patterns in development: what about the horse part?
TL;DR: Recent developments in Turing models may underlie a variety of patterning or morphogenetic processes across a wide range of model systems are reviewed.
Journal ArticleDOI
The fin-to-limb transition as the re-organization of a Turing pattern.
TL;DR: Evidence is provided that the skeletal patterning of the catshark Scyliorhinus canicula pectoral fin is likely driven by a deeply conserved Bmp–Sox9–Wnt Turing network, and that the broad morphological diversity of the distal fin and limb elements arose from the spatial re-organization of a deeply conserve Turing mechanism.