R
Ruud J.T. Smeenk
Researcher at University of Amsterdam
Publications - 67
Citations - 4342
Ruud J.T. Smeenk is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 31, co-authored 67 publications receiving 4239 citations. Previous affiliations of Ruud J.T. Smeenk include Radboud University Nijmegen.
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Journal ArticleDOI
Range of antinuclear antibodies in "healthy" individuals
Eng M. Tan,T. E. W. Feltkamp,Josef S. Smolen,Brian T. Butcher,Roger L. Dawkins,Marvin J. Fritzler,Tom P. Gordon,John A. Hardin,Joachim R. Kalden,Robert G. Lahita,Ravinder N. Maini,J. S. McDougal,Naomi F. Rothfield,Ruud J.T. Smeenk,Yoshinari Takasaki,Allan Wiik,Merlin R. Wilson,James A. Koziol +17 more
TL;DR: It is recommended that laboratories performing immunofluorescent ANA tests should report results at both the 1:40 and 1:160 dilutions, and should supply information on the percentage of normal individuals who are positive at these dilutions.
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Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.
TL;DR: The results suggest that the capacity of an antigen to induce PGE2 synthesis may play a crucial role in the development of either a Th1 or Th2 response.
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Assessment of antibodies to double‐stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor α: Findings in open‐label and randomized placebo‐controlled trials
TL;DR: Anti-dsDNA antibodies of IgM class are induced by infliximab therapy; the frequency is dependent on the assay method used.
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A critical evaluation of enzyme immunoassays for detection of antinuclear autoantibodies of defined specificities. I. Precision, sensitivity, and specificity.
Eng M. Tan,Josef S. Smolen,J. S. McDougal,Brian T. Butcher,Doyt Conn,Roger L. Dawkins,Marvin J. Fritzler,Tom P. Gordon,John A. Hardin,Joachim R. Kalden,Robert G. Lahita,Ravinder N. Maini,Naomi F. Rothfield,Ruud J.T. Smeenk,Yoshinari Takasaki,Walther J. van Venrooij,Allan Wiik,Merlin R. Wilson,James A. Koziol +18 more
TL;DR: No single manufacturer was clearly superior to others in terms of their products' overall sensitivity, specificity, and precision in the detection of antinuclear and other autoantibodies of defined specificities.
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Nucleosomes and histones are present in glomerular deposits in human lupus nephritis.
M. C. J. Van Bruggen,C. Kramers,B. Walgreen,Jd Elema,C. G. M. Kallenberg,J. van den Born,Ruud J.T. Smeenk,Karel J.M. Assmann,S.H. Muller,Marc Monestier,Jhm Berden +10 more
TL;DR: Using polyclonal and monoclonal antihistone antisera, histones were identified in all patients with DPGN and their presence was associated with a decrease of HS staining, the first demonstration of nucleosomes in glomerular deposits in SLE nephritis.